Online ISSN: 2515-8260

Keywords : Ulcerative Colitis (UC)

Assessment of AgomelatinePossible Protective EffectinUlcerative Colitis Patients; An Overview

Amira Sobhy Mahmoud,Dalia M. Abd El Motteleb,Nevertyty Mohamed Mahmoud, Shireen Sami Mahmoud Othman

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 2926-2937

Background: Ulcerative colitis, a life-long recurrent relapsing-remitting disorder, is a type of
debilitating chronic IBD of the colon that causes a superficial mucosal inflammation in a
continuous fashion extending from the rectum to the more proximal colon, in varying extents.
The hallmark symptoms of UC include bloody diarrhea with rectal urgency and tenesmus.
Many UC patients experience extra intestinal manifestations (EIM) that involve multiple organs
like erythema nodosum, pyoderma gangrenosum and arthritis. mucosa of the GIT is exposed to
millions of antigens from the food, environment and microbiome. The epithelial barrier,
covered by a mucinous layer, is the first-line defense of the mucosal immune system, because it
provides physical separation between host immune cells and luminal microbes.
Treatment of UC consists mainly of 5-aminosalycilates (5-ASAs), corticosteroids,
immunosuppressive drugs, and monoclonal antibodies to TNF-α. Treatment success is
dependent on several factors, such as use of the right drug for the right indication (induction vs
maintenance), optimization of the dose, and maximization of drug adherence (non-adherence to
mesalazine is associated with increased rates of relapse).Treatment should be tailored to disease
activity (mild, moderate, severe) and the extent of colonic involvement (proctitis, left-sided
colitis, or pancolitis).
Agomelatine is an atypical antidepressant with a unique receptor profile, as a melatonin
receptor (MT1 and MT2) agonist and a 5-HT2C receptor antagonist.

Oral Manifestation of Inflammatory Bowel Disease in Tertiary Care Centre Hospital in South-Eastern Part of India: A Prospective Study

Dr. Sanat Kumar Bhuyan; Dr. Ruchi Bhuyan; Dr. Manoj Sahu; Akankshya Sahu; Sidhant Bhuyan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 813-818

Background: Cohn’s disease (CD) and ulcerative colitis (UC) remain two different chronic digestive disease that coming below the inflammatory bowel disease (IBD) group. Abdominal cramps, vomiting, and ulceration of the digestive tract are all signs of IBD. Follic acid and ironanaemia have occurred due to improper absorption of vitamins B,& D. Bothmalnutrition and anaemia cannister source severe oral health problems, along with erythema, oedema, and angular cheilitis, burning mouth syndrome i.e. sensation in the mouth, candidiasis, lichen planus and gingivitis. Aim: The main aim of the study was to record the different oral events in patients with IBD in a tertiary carehospital in south eastern part of India. Methods: The study included 100 patients with inflammatory bowel disease. All patients had an oral examination and data was collected in prescribed format. Results:Out of 100 patients in 54 patients IBD were studied i.e. 42 CD patients and 12 UC patients.CD was most frequently seen in female (66.66%) than male (33.33%) patients and age group ranged from 31 years to 60 years. More possibilities of IBD seen in patients having poor nutritional status habits, bruxism seen in 53 IBD patients i.e. 42 patients having CD and 11 patients having UC, temporomandibular disorder also seen and most frequent of hyper mobility in 35 patients and clicking in 18 patients.Decayed teeth mostly seen i.e. 46.3% , filled teeth was 42.6% and missing teeth was 11.1%. The most frequent findings were those of periodontitis (85.18%) and gingivitis (85.18%) followed by oral ulcer (81.48%), lip swelling (77.77%) and other lesions like gingival erosion (66.66%), lip crust (79.62%), mucosal tags (55.55%) and mucosal erosions (5.55%) were found in patients and these were highly seen in CD patients (77.77%) than UC patients (22.22%). Conclusion: Systematic oral manifestations may be considered as the initial diagnostic evaluation of patients with suspected CD. Early diagnosis will result in better treatment and pronostics for the patient.