Online ISSN: 2515-8260

Keywords : liver fibrosis

Differential Recruitment of Monocytes Subsets in Chronic Hepatitis C Patients

Nora E. El-Bassiouni; Mona E. Madkour; Raafat I. Atta; Mohamed D. El Talkawy; Azza M. El Amir; Alyaa A. Farid; Noha A. Amin

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 6071-6082

Background: Collagen producing myofibroblast activation of is critical for pathogenesis of liver fibrosis. Aim of the work: To study the expansion of peripheral monocyte subsets in HCV patients. Subjects and Methods: Sixty HCV patients were classified according to METAVIR score into 4 stages of liver fibrosis, 15 age and sex-matched controls were include. Flowcytometric analysis of peripheral blood monocytes subsets and CCR2+ve cells was
carried out using monoclonal anti-CD45, anti-CD14, anti-CD16, anti-collagen type I and anti-CCR2antibodies. MCP-1 and SAP levels were assessed using ELISA. Results and Conclusions: A down regulation (p< 0.01) in the classical monocytes subset and an up regulation (p< 0.01) in both the non-classical monocytes and monocytes
producing collagen subsets were notice in HCV patients compared to controls. A marked increase (p< 0.01) in the levels of MCP-1 and monocytes expressing CCR2 with a significant decrease (p< 0.01) in SAP levels, which paralleled the progression of liver fibrosis, were also noticed. MCP-1 and CCR2 may trigger monocytes recruitment to the injured liver promoting the development of collagen type I producing monocytes. The shift
of classical monocyte subset towards the non-classical and collagen producing subsets may be present a predictive non-invasive biomarkers for progress of liver fibrosis.

Global Burden on Alcoholic Liver Diseases

Jagankumar Ojha; Kalpana Shee; Puspanjali Mahapatra

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 1069-1078

The cause of alcoholic liver disease (ALD) is heavy alcohol consumption. The ALD spectrum includes steato-alcohol, steatosis, fibrosis and cirrhosis. Around 52% of cirrhosis-related deaths in western countries are caused by consuming alcohol. Alcoholic cirrhosis is no longer considered an irreversible condition, although there are currently no effective anti-fibrotic therapies. Specific factors influence the growth and development of alcoholic liver disease (ALDs), including the duration and volume of liquor intake. ALD reflects a variety of liver disorders from greasy alterations toward fibrosis to cirrhosis. Initialanalysis of ALD remains critical in order to promote liquor abstinence, reduce the growth of liver fibrosis, and handle complications connected to cirrhosis with hepatocellular carcinoma. The drug in taking screening is used in a variety of questionnaires and laboratory tests. In 2010 the global approach of the research on burdens of alcoholic liver and alcohol related liver cancer was used for estimating Living years adapted also for burden of illness (DALY). This method measures the related percentages cantered on the alcohol consumption rate and the likely effects of specific product concentrations. In 2010 global liver cirrhosis caused by alcohol was due to 493,300 deaths, 14,545,000 daily deaths, reflecting 0.8% (0.8% women's and 1.3% men's) 0.6% of worldwide or 0.4% of the world average deaths among females or 0.8% of males and 47.7% (46.4% women and 48.6% men's) of all liver cirrhosis. The cause of 80,500 deaths was alcohol-related liver cancer.