Online ISSN: 2515-8260

Keywords : Inflammatory Bowel Disease

Histopathological Spectrum of Lower Gastro-Intestinal Colonoscopic Biopsy Lesion With Special Reference To Her-2/Neu Expression In Carcinoma Colon

Debahuti Mohapatra; Rupanita Biswal; Mitu Mohanty; Prateek Das

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 1150-1159

Introduction :
Cancer associated with colon is one of the principal risk factors from decease in women and men. Although importancegrowing aspect of human epidermis receptor2 (Her2)as atherapeutic target is rising butits role as a biomarker in form of predicting indicator indicatorwithin colorectal cancer(CRC)is stilla mystery.Present research isundertakenfor evaluating the of Her2/neu description in cancer of colon.
Material & Method :
This research comprises 256patientswith spectrum of histopathological treatment ranging from colitis to colorectal carcinoma at our department between 2015- 2017. Her2/neu Immunohistochemistry was done in the colorectal carcinomaand scores based on Ruschoff et al (2012) Her-2 testing in gastric cancer.
Result :
Out of total number of 256 cases enrolled in our study group, majority belonged to the age group of 40-60 years, with M:F ratio being 1.4:1. Commonest site of lesion occurred in rectum (43.75%) followed by ascending colon and caecum (12.08%). Non neoplastic lesions constituted about two third of all cases, the commonest being inflammatory bowel disease(21.48%). In benign neoplastic lesions of tubular adenoma was thecommonest type, and in malignant commonest type was colorectal adenocarcinoma NOS(64.44%) followed by mucinous adeno carcinoma (22.22%). Because of more prominent membranous staining observed in high grade colorectal cancers, Her2neu expression is found to be an important predictive marker of carcinoma colon, especially the adenocarcinoma,NOS.
Conclusion : Like Breast carcinoma, target oriented therapy can be instituted especially in Her 2/neu positive high grade and metastatic tumors.

Alternative Herbal Medicines For Prevention And Treatment Of Ulcerative Colitis

Vishal Dubey; Sima Singh

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4900-4907

Drugs such as adreno-corticosteroids, corticosteroids, purine analogues, antibiotics, immunomodulators, and 5-aminosalicylic acid have become the foundations in management therapy for Ulcerative Colitis (UC). These medicaments remain available in the variety of forms are used an orally and topically to reduce inflammation of the colon and rectum. There can be seen the imbalance of intestinal beneficially acting bacteria triggered an inapt, intense, and enduring mucosal immune retort that leads to the intestinal tissue impairment in an individual. Nonetheless, all these drugs are useful for treatment tolerated with some shortcomings side-effects. From the beginning to the end of human life, natural plants or plant products play an important part. In this existing review, the authors summarize the revisions relating to the natural products practiced by UC patients as a substitute management process for each induction or upkeep management.