Online ISSN: 2515-8260

Keywords : Colorectal Cancer


Relation between Serum Carcinoembryonic Antigen and Tumor Node Metastasis (TNM) Staging of Colorectal Cancer

Nouralddeen Ahmed Kareemeed, Alaa Mohamed Ibrahim Khalil, Wael Elsayed Lotfy Mokhtar, Hassan Rabea Galal Ashour

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3369-3377

Background: Colorectal cancer (CRC) is the third most commonly diagnosed cancer
and the fourth leading cause of cancer death worldwide with steadily increasing
mortality rates. The aim of the present study to highlight any relationship between
carcinoembryonic antigen (CEA) and tumor node metastasis (TNM) stage in
colorectal cancer (CRC) patients that would help in diagnosis and staging of the
disease. Patients and methods: A total of 36 patients with stages IV CRC were
admitted to department of General surgery, Zagazig university hospitals and
underwent surgery. Full medical history, clinical examination, General and specific
investigation were performed for all patients preoperatively.The CEA levels for all
patients were examined preoperatively. Results: Our study showed the mean age of
the studied cases ranged from 29 to 83 years with mean 54.36 years. Regarding sex
63.9% were male. Finally 38.9% were smoker. Most common sites of lesions were
rectum, sigmoid colon & descending colon (44.4%, 19.4% & 13.9% respectively).
The diameter of lesion among cases ranged from 1 to 15 cm with mean 5.94 cm and
38.9% had diameter from 3 to 6 cm. Regarding differentiations most frequent was
moderate and mild (41.7% & 30.6% respectively). CEA level among the studied cases
ranged from 0 to 23 ng/dl with mean 6.39 ng/dl and median 4.5 ng/ml. Also 58.3%
had CEA level ≤ 5 ng/ml. Conclusions: There is a meaningful link between TNM
stage and CEA level. However, normal levels of CEA will not rule out CRC
diagnosis, and it can be concluded that these patients should be investigated in
detail

Histopathological Spectrum of Lower Gastro-Intestinal Colonoscopic Biopsy Lesion With Special Reference To Her-2/Neu Expression In Carcinoma Colon

Debahuti Mohapatra; Rupanita Biswal; Mitu Mohanty; Prateek Das

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 1150-1159

Introduction :
Cancer associated with colon is one of the principal risk factors from decease in women and men. Although importancegrowing aspect of human epidermis receptor2 (Her2)as atherapeutic target is rising butits role as a biomarker in form of predicting indicator indicatorwithin colorectal cancer(CRC)is stilla mystery.Present research isundertakenfor evaluating the of Her2/neu description in cancer of colon.
Material & Method :
This research comprises 256patientswith spectrum of histopathological treatment ranging from colitis to colorectal carcinoma at our department between 2015- 2017. Her2/neu Immunohistochemistry was done in the colorectal carcinomaand scores based on Ruschoff et al (2012) Her-2 testing in gastric cancer.
Result :
Out of total number of 256 cases enrolled in our study group, majority belonged to the age group of 40-60 years, with M:F ratio being 1.4:1. Commonest site of lesion occurred in rectum (43.75%) followed by ascending colon and caecum (12.08%). Non neoplastic lesions constituted about two third of all cases, the commonest being inflammatory bowel disease(21.48%). In benign neoplastic lesions of tubular adenoma was thecommonest type, and in malignant commonest type was colorectal adenocarcinoma NOS(64.44%) followed by mucinous adeno carcinoma (22.22%). Because of more prominent membranous staining observed in high grade colorectal cancers, Her2neu expression is found to be an important predictive marker of carcinoma colon, especially the adenocarcinoma,NOS.
Conclusion : Like Breast carcinoma, target oriented therapy can be instituted especially in Her 2/neu positive high grade and metastatic tumors.