Online ISSN: 2515-8260

Keywords : OSCC


p53: The Guardian of Genome Against OSCC Progression

Astari Puteri; Asti Meizarini

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 10, Pages 1071-1079

Protein 53 (p53) plays a vital role in the human body, mainly as tumor suppressor protein, by inhibiting tumor cell formation and DNA damage through gene target regulation. Known as "guardian of genome", p53 protects genome integrity and prevents cells' proliferation with damaged DNA. In oral squamous cell carcinoma, there is approximately 85% mutation of p53, which leads to impairment of its normal function and often correlated with OSCC progression. Those findings signify the role of p53 in guarding against OSCC, which are through cell cycle arrest, DNA repair, and apoptosis.

Oral Cancer: A Retrospective Study of a Decade

Dr. Ruchi Bhuyan; Dr. Sanat Kumar Bhuyan; Sidhant Bhuyan; Akankshya Sahu

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 1200-1207

Introduction Head besides neck cancer(HNC) The word "avast" contains a variety of malignancy sites, including numerous oral cavity locations, such as maxilla, mandible, tongue, oral floor, oral mucosa, gingiva, mouth or pharynx and larynx. mouth cancer is amongst the most frequent cancers in tumors. The purpose of this research is to investigate the occurrence of HNC as well as its association with traditions, age , gender and place throughout India.
Aim: The goal of the research was to document the effect on Odisha coastal communities in East India for Head / Neck Cancer (HNC) and also its meanings by behaviors, age , gender as well as location.
Materials and methods: A study was conducted retrospectively between June 2009 and June 2019. A maximum of 1364 OSCCs (Oral squamous tissue carcinoma) were analysed with the results were statistically analyzed.
Result: Ratio of men to women 2:1 as well as average age between 40 and 59 years. Oral mucosa (48,97%) including tongue (16,49%) or maxila (6,94%) are now the most popular site for cancer, accompanied by lip (1 24%). Tobacco cigarettes and nibbling habits were prevalent amongst these people of eastern India as well as represented the greatest potential risk for onset of disease. Besides that, a strong relationship with OSSC has been discovered in the smokeless type with tobacco, particularly in females.
Conclusions: The result of this evaluation reveals the use of tobacco is among the main reasons for increasing oral cancer malignancy development. Therefore, it is important for an individual to be informed of this tobacco-linked cancer growth.