Online ISSN: 2515-8260

Keywords : multi drug resistance

ClinicalStudy ofBacteriologicalPatterns andAntibiotic Sensitivity in Secondary Peritonitis

Naveen Banoth, Venkatesh A

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2461-2472

Background:Intra-abdominal infections have been treated with various antibiotic regimens. These infections have been treated with single-agent and combination treatments. But no one therapy has been proven superior. The study's main goal is to examine the bacterial patterns in peritoneal fluid from surgical peritonitis patients and assess their antibiotic sensitivity and resistance.
Materials and Methods: It is a cross sectional observation research conducted in January 2020 to May 2021 which was conducted in JSS Hospital Mysuru. Analyzed data was in rates, proportions, and percentages. The sample includes 100 cases of secondary peritonitis caused by hollow viscus perforation, where preoperative peritoneal fluid samples were analysed for bacterial culture and sensitivity.
Results: Out of 100 samples, 50 had bacterial growth. The most common bacteria were E. coli. These were Acinobacter (6%), Candida (4%), Citrobacter (1%), Klebsiella (11%) and Serratia (2%). (4 percent). 77.5 percent of E. coli were sensitive to Ceftriaxone, 75% to Piperacillin-tazobactam, and 99.1 percent to Meropenem. In 40% of cases, E.coli was multidrug resistant. Most Klebsiellapneumoniae were responsive to ceftriaxone, piperacillin-tazobactam, and meropenem. Ciprofloxacin, Ceftriaxone, and Meropenem were all sensitive to Proteus mirabilis. 25.2 percent of cases were multidrug resistant bacteria.
Conclusion: The results of this investigation identify the organisms usually isolated from peritoneal fluid, their susceptibility and resistance to broad spectrum antibiotics. It shows the common gramme negative isolates and the current antibiotic resistance concern in these individuals. The most common microorganism found in gastrointestinal perforations is Escherichia coli. In most cases, numerous gramme negative bacilli develop polymicrobially. Antibiotic-resistant microorganisms, notably multidrug resistant Escherichia coli, are increasing in number. Third generation cephalosporins are becoming more resistant. In multidrug resistant organisms, Meropenem and Tigecycline seem to be the best options.

Phytochemicals as new class of antibiotics to control Multi Drug Resistance

Satish Kumar Sharma; Tejinder Kaur

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 1433-1442

Phytochemicals represent traditional knowledge of compounds effective in symptomatic relief and potential healing properties. The idea has emerged from the fact that natural resources such as neem, turmeric, cloves etc. have been used to cure health problems since a really long time. Even in the current modern world, people have more preference towards natural therapeutics than modern drug formulations. Antibiotics are the drugs which are most easily prescribed unnecessarily to attain extremely rapid symptomatic relief. The practice has led to natural selection of resistant bacterial strains which are spreading at an alarming rate. The world without antibiotics is horrible to contemplate and can cause uncontrollable mortality rate in future due to resistant bacterial infections. The review elaborates importance of phytochemicals as compounds of natural origin, easy production, industrialization scope, broad spectrum antibacterial capabilities to tackle the crisis of antibiotics in the ever growing era of multi drug resistance