Online ISSN: 2515-8260

Keywords : Subclinical hypothyroidism


Subclinical Hypothyroidism in Pregnancy: A Review

Dr. Ritimukta Panda; Dr. Kavya Sudha; Dr. K.Jaya Sri; Dr. Rachita Sarangi; Dr. Bhagirathi Kar; Dr. Gangadhar Sahoo

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 1443-1446

Pregnancy-reference levels of Subclinic hypothyroidism (SCH), along with normal level of serum thyroxine, are called high thyroid stimulation hormone level (TSH).
Autoimmune Thyroiditis is also common in patients of subclinical hypothyroidism. Subclinical Hypothyroidism in pregnancy is the cause of some adverse obstetric consequences. Changes in the metabolism of thyroid hormones during pregnancy needs to be kept in mind, while diagnosing thyroid abnormalities. There is a jump in the obstetric and neonatal results, like preterm delivery, miscarriage, fetal growth restriction, preeclampsia, gestational diabetes mellitus, low birth weight, abruptio placentae and poor Apgar scores at birth. Treatment with Cevothyroxine therapy may help reduce some of these adverse effects, however there is restricted evidence to provision it. The behavior of subclinical hypothyroidism should target maternal TSH concentrations of less than 2.5mIU/L. However there is a lack of recommendation for the official starting dose of levothyroxine. So, individualised low doses of levothyroxine can be started and thereafter titred to the maintain the TSH in the target level

Assessment of glycated haemoglobin level in non-diabetic overt hypothyroid patient

VidyaSagar Ram,Amit Varshney

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 5, Pages 1960-1964

Background: Dysfunction and anatomic abnormalities of the thyroid are among the most
common diseases of the endocrine glands. Almost one-third of the world’s population lives
in areas of iodine deficiency and present study determines the association ofglycated
haemoglobin level in non-diabetic overt hypothyroid patient.
Materials & Methods:130 subjects of both genders were divided into 2 groups. Group I
comprised of 70 patients with overt hypothyroidism and group II were 60 subjects (control
group) with no thyroid dysfunction. HbA1c was measured by immunoturbidimetry method
by clinical chemistry analyzer and serum TSH and FT4 were measured by radio immune
assay.
Results: Common clinical features were hoarseness of voice in 65%, fatigue in 53%,
weight gain in 70%, depression in 42%, puffy face in 35%, non- pitting edema in 39%, cold
intolerance in 31% and constipation in 22%. The mean TSH level in group I was 18.2
mIU/l and in group II was 3.4 mIU/l, FT4 level was 5.0 pmol/l in group I and 12.4 pmol/l
in group II, HbA1c level was 5.9% in group I and 5.2% in group II and FBS level was 5.2
mmol/l in group I and 4.7 mmol/l in group II. The difference was significant (P< 0.05).
There was correlation between TSH and HbA1c levels (r- 0.412, p< 0.05).
Conclusion: Hypothyroid patients had high level of glycatedhemoglobin level as compared
to control subjects