Online ISSN: 2515-8260

Keywords : Postpartum Hemorrhage

Efficacy of Tranexemic Acid in Prevention of Hemorrhage after Vaginal Delivery Postpartum

Moustafa Mohamed Ali, Wael Hussien El-Bromboly, Walid Mohamed Elnagar and Mohamed Fathy Abou Hashem

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 503-512

Background: Postpartum haemorrhage is still the primary cause of maternal
death, particularly in underdeveloped nations. We aimed to see how tranexamic
acid and oxytocin compare in terms of preventing postpartum haemorrhage and
lowering blood loss, hospital stay, morbidity, and death during vaginal
birth.Patients and methods: A prospective, randomised clinical trial study was
conducted on 92 pregnant women who were being prepared for vaginal delivery
and were divided into two groups: Group (A) (TXA group) (46 patients) received 1
gm of tranexamic acid and Group (B) (Non-TXA group) (46 patients) received 10
IU of oxytocin. Hemoglobin and hematocrit readings were tested before and 24
hours after vaginal delivery, and additional basic laboratory tests were
performed.Results: In our study, there was no significant difference in HB at the
pre-test, but the Non-TXA group was considerably lower at the post-test, and the
Non-TXA group had a significant reduction. At the pre-test, there was no
significant difference in HCT, but the Non-TXA group was considerably lower at
the post-test, and the Non-TXA group had a significant reduction. In the TXA
group, the difference in HCT was much smaller. The TXA group had considerably
less blood loss.Conclusion: The use of tranexamic acid during delivery may assist to
minimise blood loss. It is a low-cost and widely available medication. The use of
TXA reduces the requirement for uterotonics, lowering morbidity and mortality.

Retrospective analysis of the birth histories of women who have suffered bleeding in order to optimize approaches to the prediction and prevention of postpartum bleeding

Poyonov O. Yoldoshevich; Karimova N. Nabidjanovna

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 6236-6243

The aim of our study was to retrospectively examine the history of childbirth and the quality of primary care for bleeding and evaluate the prescribed rehabilitation measures for women who have suffered postpartum hemorrhage and massive bleeding. The materials and methods of the study were 242 birth histories with postpartum hemorrhage for the last 6 years (2013-2018) in the city maternity hospital of Bukhara. The average age of the patients was 26.7 ± 1.2 years. The obstetric pathology leading to bleeding mainly consists of uterus hypotonia - 143 (59.1) and large fetus - 68 (28.1), and preeclampsia and DIOV are equal amounts - 33 (13.64). Only about 20% of women who had postpartum hemorrhage underwent early rehabilitation in the form of prescribing contraceptives.The aim of the research was to study the effectiveness of modern principles of stopping postpartum obstetric bleeding. From 127 cases of bleeding in 101 women (79.5%) the childbirth were with the operational method. With the development of blood loss was renderedstepwise ways to stop bleeding. During hemostasis of the bleeding, ligatures were imposed on the ovarian arteries and the ascending branch of the uterine artery for ischemicization of the uterus, which was effective in 30 (30%) women, and in 114 (89.7%) women managed to achieve organ-sparing tactics.