Online ISSN: 2515-8260

Keywords : monooxygenase system


Effect Of Pesticides On The Content Of Cytochrome P-450 Of The Monooxygenase System And On The Ultrastructure Of Hepatocytes In Rat Embryos

Tuychieva Dilfuza; Mirkhamidova Parida; Parpieva Mashhura; Babakhanova Dilnoza; Alimova Rano

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 2473-2483

Our results show that the pesticides butylcaptax, dropp and karate are highly toxic pesticides, when exposed to these pesticides, the activity of the enzyme of the P-450 monooxygenase system is disrupted. Also, the research results showed that when poisoning with the above pesticides, ultrastructural, and therefore functional changes in the subcellular components of embryonic hepatocytes occur. When using RAF (plant antioxidant factor), enzyme activity and other indicators are significantly restored, which indicates that RAF has antioxidant properties.

NFLUENCE OF INDUCTION AND INHIBITION OF THE MONOOXYGENASE SYSTEM OF THE LIVER ON THE THYROID STATUS OF THE RAT'S BODY

Abzalova Sh. R.; Yuldashev N. M.; Rasulova M. T.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3235-3246

In order to assess the dependence of the thyroid status of the organism on the functional state of the monooxygenase system of the endoplasmic reticulum of hepatocytes in sexually mature male rats, induction and inhibition of the monooxygenase system of the liver by its inductors and inhibitors was caused. As inducers, we used known induction drugs - benzonal (benzobarbital) and zixorin (flumecinol), and as inhibitors a chemical compound - cobalt chloride and a blocker of histamine H2-receptors - cimetidine. Benzonal was administered orally at a dose of 50 mg / kg body weight for 3 days, and zixorin was administered at a dose of 40 mg / kg body weight for 4 days. Cobalt chloride was administered once intraperitoneally at a dose of 30 mg / kg of body weight, and cimetidine was administered orally at a dose of 100 mg / kg for 10 days. It was revealed that during the induction of the monooxygenase system of the liver by its inductors - benzonal and zixorin, there is an increase in the content of thyroid hormones - triiodothyronine and thyroxine in the blood against the background of no change in the level of thyroid-stimulating hormone. When the monooxygenase system of the liver is inhibited by its inhibitors - cobalt chloride and cimetidine, an increase in the content of thyroid hormones - triiodothyronine and thyroxine in the blood is also observed, but against the background of a statistically significant decrease in the content of thyroid stimulating hormone. It is concluded that there is an indirect relationship between the functional state of the monooxygenase system of the liver and the thyroid status of the body.