Online ISSN: 2515-8260

Keywords : microsome


Effect Of Pesticides On The Content Of Cytochrome P-450 Of The Monooxygenase System And On The Ultrastructure Of Hepatocytes In Rat Embryos

Tuychieva Dilfuza; Mirkhamidova Parida; Parpieva Mashhura; Babakhanova Dilnoza; Alimova Rano

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 2473-2483

Our results show that the pesticides butylcaptax, dropp and karate are highly toxic pesticides, when exposed to these pesticides, the activity of the enzyme of the P-450 monooxygenase system is disrupted. Also, the research results showed that when poisoning with the above pesticides, ultrastructural, and therefore functional changes in the subcellular components of embryonic hepatocytes occur. When using RAF (plant antioxidant factor), enzyme activity and other indicators are significantly restored, which indicates that RAF has antioxidant properties.

Influence Of Karate On The Activity Of Enzymes Of The Anti-Oxidizing System Of Rat Liver Protection And Ways Of Their Correction

Parida Mirkhamidova; Dilfuza Tuychieva; Dilnoza Bobokhonova; Mashkhura Parpieva

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3757-3765

As a result of research, it has been established that synthetic karate pyrethroid causes functional changes in antioxidant enzymes in microsomes and mitochondria. An important aspect of our study was the comparison of the taxation rate when animals were poisoned with a karate pesticide and when animals were protected from poisoning with an antioxidant of plant origin. The results obtained indicate that the plant antioxidant factor (PAF) has protective properties and accelerates the restoration of enzyme activity.