Online ISSN: 2515-8260

Keywords : Pneumonia


Ilxamdjan Karimdjanov Asamovich; Nozima Sаdiqova Baxadirovna; Botir Tadjiev Mirkhashimovich; NurlanDinmukhammadiev Aktamovich; Bobir MirkhashimovBotirovich; Yaxyayeva Komola Zokirovna; Anvar Tursunbayev Karimberdiyevich; Fatima Xoltayeva Fayziyevna

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 1, Pages 1341-1351

The role of vitamin C in the prevention and treatment of pneumonia andsepsis has been investigated for past decades. This reviewaimsto translatethese findings into patients with severe coronavirus disease (COVID-19). It has indicatedthat patients with pneumonia and sepsis have low vitamin C status and elevated oxidative stress.Additional oral or intravenous (IV) vitamin C administered patients with pneumonia can mitigate the severity and course ofthe disease. Severely ill patients with sepsis need for intravenous administration of amounts counted in grams ofthe vitamin to achieve adequate plasma levels, an intervention that some studies suggest reduces mortality.The vitamin has physiological functions like pleiotropic, many of which are closely connected to COVID-19.These are its antioxidant, antiinflammatory, antithrombotic and immunomodulatory functions.Previous observational studies found out low vitamin C status in critically ill patients with COVID-19.A number of randomized controlled trials (RCTs) conductedworldwideevaluate intravenous vitamin C as monotherapy in patients with COVID-19. Optimization of the intervention protocolsin future trials, e.g., earlier and continuously administration, is justified to potentially improve itsefficacy. In order to the excellent safety profile, low cost, and potential for rapid enlargement of production,administration of vitamin C to patients, especially with hypovitaminosis C and severe respiratory infections,e.g., COVID-19, appears warranted. In addition, there are few new ways of concurrent using vitamin C and other manipulations or medications.

PNEUMONIA: Natural History Laboratory Abnormality In COVID 19

Linny Luciana; July Kumalawati

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 2687-2694

Introduction: COVID19 is a new disease caused by the SARS CoV 2 virus which became pandemic in 2019. In October 2020, COVID 19 cases in Indonesia continued to increase, reaching 304,007 cases. The mortality rate of this disease is 3.6%. This disease shows many symptoms such as asymptomatic, fever, cough, diarrhoea, severe shortness of breath.
Case: 53 years-old man with fever for five days with cough, sore throat, and tightness. Physical examination revealed a temperature of 38 °C and bilateral lung crackles with ground-glass opacity of the right lung in pulmonary CT scan. PCR results obtained positive SARS-CoV 2.
Discussion: In the early phase of COVID19 infection, complete peripheral blood tests tended to be normal with a mild increase in CRP. When ARDS occurs, there is a significant decrease in absolute lymphocyte, and increased CRP levels. The decreased Hb levels accompanied by increased LDH is suspected hemolysis of erythrocyte. Other laboratory examination shows an increase of acute phase reactants such as D dimers, fibrinogen, and ferritin that indicate a severe inflammatory state. By the progression of the disease, laboratory abnormality such as decreased absolute lymphocytes and increased inflammatory markers happened on the 12th day after symptoms.

State Of The System In Patients With Hospital Respiratory Disorder Within The Background Of Chronic Nephrosis

Botir T. Daminov; Lola T. Daminova; Nodirjon Z. Asadov; Davron K. Muminov

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3482-3492

Purpose of the study: to check some indicators of the immunohemogram in patients with community acquired respiratory disorder on the background of CKD.
Materials and methods. one hundred twenty patients with community-acquired respiratory disorder were examined: forty patients with respiratory disorder (group Pn) and eighty respiratory disorder, that developed against the background of chronic nephrosis (group Pn+ CKD). The management cluster (CG) consisted of twenty healthy individuals. The study found that the amount of leukocytes was exaggerated within the Mon + CKD cluster by 162.24% than in the CG (p <0.001), within the Mon cluster 263.14% on top of within the CG and twenty seven.79% than within the cluster Mon + CKD (p <0.001). In patients with Mon, the quantitative relation of the amount of neutrophils to lymphocytes significantly exaggerated (p <0.001 compared with the CG and also the Mon + CKD group), reflective the shift of the formula to the left, and within the Mon + CKD cluster this quantitative relation remained unchanged, despite the increase within the absolute variety of leukocytes. In patients with respiratory disorder with background CKD, a marked increase in T-lymphocytes was determined because of a population of CD8 and CD95 cells (p <0.001 compared with CG and also the Mon group). a rise in IgM concentration prevailed within the pneumonia cluster, and a rise in immune serum globulin prevailed within the PN + CKD cluster (p <0.001).
Conclusion. Respiratory disorder related to CKD is related to associate active general inflammatory response involving non-specific immunity and also the depletion of its cellular part, as well as activation of immunity because of chronic inflammation and chronic matter stimulation.

Out-Of-Social Pneumonia On The Background Of Chronic Kidney Disease

Lola T. Daminova; Nodirjon Z. Asadov; Davron K. Muminov

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3493-3504

Objective: to investigate the characteristics of the clinical course of community-acquired pneumonia in patients with constant kidney infection. The ponder included 120 patients with pneumonia: 40 patients had no history of renal pathology (group M), 80 patients endured from inveterate kidney infection (GFR for 3 months some time recently the improvement of pneumonia 30-60 ml / min / 1.7 m2, group M + CKD ). Confirmation of the determination was carried out on the premise of chest X-ray, the detailing of the conclusion included deciding the sort of pneumonia - croupous or central intersecting.
In a comparative evaluation of the X-ray picture within the explored groups, it was famous that in patients with pneumonia against the foundation of CKD, lobar and central intersecting pneumonia with a huge penetrate volume were altogether more frequent (p <0.001). Within the flow of follow-up, the larger part of patients (78 out of 120 patients, 65%) appeared positive clinical and radiological elements, 20 patients (16.67%) appeared no critical elements, and 22 patients (18.33%) had clinical and radiological elements. negative. Negative clinical and radiological flow was more frequently watched within the group of patients in whom pneumonia developed against the background of CKD (p <0.01).

A Review Study On Relationship Among Covid-19 And Pneumonia

Dr.Akila K; Dr.Senthil Nathan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5476-5480

First declared as a coronavirus disease by the World Health Organisation (WHO) in March 2020 (COVID-19), the number of Positive and death cases continues to rise even seven months after that. Seven months later. This global pandemic has had a huge effect on the world's health, social and economic facets. Therefore, it is necessary to recognise the risk factors that lead to the production of serious infections for risk stratification, to improve the re-allocation of hospital resources and to direct guidelines and strategies on public health. A variety of co-morbidity consequences such as hypertension, diabetes, dyslipidemia, anaemia, coronary, thyroid disease, and pulmonary disease have been shown to be correlated with serious COVID-19 findings 1. Persons with dementia are the most fragile in normal times as they rely on others for their daily life. In a recent review, dementia has been found to increase the risk of morbidity and death, including incidence of respiratory illness, of hospitalising patients. Unfortunately, until now, no research has shown specifically how dementia is linked to COVID-19. This paper seeks to investigate the theoretically related implications of COVID-19 infection with dementia.

Modern Approaches To The Selection Of Protected Cephalosporins Iii For Therapy Of Community-Acquired Pneumonia In Children

Mukhlisakhon Ravshanhanovna Kurbanova; Furkat Mukhitdinovach Shamsiev; Rano Anvarbekovna Musajavova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3008-3014

The aim of the study was to study the effectiveness of the use of protected cephalosporin III generation Extum in the treatment of community-acquired pneumonia in children. The study included 100 children with community-acquired pneumonia at the age from 1 to 15 years, who were observed and treated in the department of pulmonology. In the process of complex clinical and laboratory examination of children, biochemical, microbiological and immunological research methods were used. Microbiological studies have shown that in children with community-acquired pneumonia, S. Pneumonia occupies a significant place in the etiological structure and accounts for 42.0% of cases, a high sensitivity of pneumococcus to injectable cephalosporin of the third generation has been established. When included in complex treatment, protected cephalosporin of the third generation Extum leads to a decrease in the frequency of repeated acute respiratory infections and their complications by 2.2 times, the frequency of recurrent bronchitis and pneumonia by 1.7 times, which indicates a high therapeutic effectiveness of the proposed treatment

Epidemiological study of COVID-19 pneumonia in pregnant woman and their neonates; report of thirteen confirmed COVID-19 pregnant women

Alireza Kamali; Behnam Mahmodiyeh; Amir Almasi-Hashiani; Morteza Mousavi Hasanzadeh; Maryam Shokrpour

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 4455-4461

Background: In new pandemic, the probable effects of COVID-19 pneumonia on pregnant woman and their infant is one of new critical challenge for health care. Here we presented clinical symptoms, laboratory findings and outcome of COVID-19 pneumonia in pregnant woman. Methods: In a case series study, from 15 Feb to 15 June 2020, all women with RT-PCR COVID-19 who referred to two hospitals (Taleghani and Qods Hospital) affiliated to Arak University of Medical Sciences were selected. The epidemiological and demographic variables, laboratory test and outcomes obtained from patient’s medical records. Results: In this case series, we presented thirteen confirmed COVID-19 pregnant women. Their mean age was 34.6 (S.D.: 5.9) years and the mean gestational age was 32.4 (S.D.: 7.3) weeks. Most of patient didn’t show any maternal complication and intrauterine vertical transmission. The large number of pregnant women had normal HRCT and also in terms of laboratory most of the patients had normal laboratory tests. Amniotic fluids, cord blood, the throat swab of neonate in our pregnant woman with delivery were tested for COVID-19 and all of them were negative. Conclusion: The COVID-19 mothers and their infant didn’t have higher risk for morbidity and mortality and this virus didn’t associate with intrauterine vertical transmission.