Online ISSN: 2515-8260

Keywords : pneumonia


A study to assess the level of Vitamin D status and its association with the severity of the pneumonia

Syed Shah Sarmast, Rajendra Shinde, Priyanka More, SK Satpathy

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 822-827

Background: The effects of Vitamin D on bone metabolism and calcium homeostasis have
already been well recognized. Emerging evidence has implicated Vitamin D as a critical
regulator of immunity, playing a role in both the innate and cell-mediated immune systems.
Emerging evidence has implicated Vitamin D as a critical regulator of immunity, playing a
role in both the innate and cell-mediated immune systems. Vitamin D deficiency has been
found to be associated with several immune-mediated diseases, susceptibility to infection and
cancer. Further elucidation of the role of Vitamin D in lung development and immune system
function may hold profound implications for the prevention and treatment of asthma.
Objective: To study the Vitamin D Status of children having severe pneumonia and to know
if there is any relation between Vitamin D levels and severe pneumonia.
Methodology: The present prospective study was conducted by the department of Pediatrics
at SCBMCH & SVVPGIP, Cuttack from October 2013 to October 2015 among the children
with the age group of 1 to 5 years of age who were admitted in the department with
complains of Pneumonia. A total of 80 children who were having severe and very severe
pneumonia diagnosed based on WHO ARI (acute respiratory tract infection) criteria admitted
to the SCBMCH & SVVPGIP (General, Pay ward & PICU) in the age group of 1 to 5 years.
Results: In this study, we found that 50% of the children among cases had vitamin D levels
in the deficiency range while 41.3% and in the insufficiency group while we had 8.8% of the
children in the sufficiency group as compared to the healthy controls 20(71.4%) among 28
belongs to sufficient age group, 5(17.9%) to insufficient group and 3(10.7%) to the deficient
group. One significant finding in this study was that out of the 27 children in the sufficiency
group none of them were there in the very severe pneumonia group which suggests as the
Vitamin D levels Increases the severity of the condition decreases.
Conclusion: In this study, we found that Vitamin D levels were related to severity of the
disease as there were no children in the sufficiency group having very severe pneumonia.
Hence we can say as the levels of Vitamin D falls the severity of pneumonia Increases.

Spectrum of Chest HRCT findings in covid-19 pneumonia

Dr. Ashok Kumar Kattimani, Dr. Shivaraj G Biradar, Dr. Neeraja Akki

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 251-257

Introduction: The pandemic disease COVID-19 has varied presentations clinically and even
radiologically. Early diagnosis and treatment help in containment of the disease. Therefore, assessing
the radiological patterns in order to contribute to the diagnosis COVID-19 is the aim of this study.
Materials and method: A cross-sectional descriptive study from January 2021 to June 2021 was
carried out on 165 patients suspected of COVID-19 with delayed RT-PCR report or in cases with initial
RT-PCR negative, but having high clinical of suspicion of COVID-19. HRCT pattern in such cases
were documented and correlated with the repeat RTPCR and other laboratory parameters such as
Interleukin IL-6, serum ferritin, C-reactive protein, Lactate Dehydrogenase.
Results: Most common HRCT pattern was bilateral multifocal peripheral ground glass opacities
predominantly involving posterior segments. Other common patterns were crazy paving and
consolidation.
Conclusion: Specific patterns on the HRCT can be used in diagnosis of COVID-19 when there is high
clinical likelihood, however the study should be used judiciously only when indicated.

Fetomaternal outcome of pregnancy with COVID-19

Dr. ChhaviBhomia,Dr. Neelima Shah, Dr. Prashant Shah, Dr. Vasudha Sawant

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 695-700

Objective: To study the Feto maternal outcome of Covid-19 in Pregnancy.
Methodology: This is a retrospective study done on 53 pregnant patients who tested positive
for SARS-CoV-2 and were delivered in D. Y. Patil Hospital, Kolhapur from April 2020 to
July 2020. Maternal and fetal characteristics and the outcome of Covid-19 infection in
pregnancy was studied.
Results: Among the 53 patients, 49 patients (92%) were asymptomatic. Remaining presented
with fever, sore throat, cough. 69% were primigravida and 30% were multigravida. 66%
underwent LSCS while 28% were delivered normally. In majority, LSCS was done for
oligohydramnios and fetal distress. All the patients were discharged after negative swab
report and no maternal death was reported. About 32% of neonates required NICU admission
for hyperbilirubinemia, pneumonia and sepsis. There was no neonatal death and none of the
neonates turned out to be positive for covid-19.
Conclusion: The severity of SARS-CoV-2 was seen to be mild to moderate in pregnant
women. Majority of the women infected with coronavirus disease were asymptomatic. The
risk of vertical transmission to the neonate was also found to be low. Oligohydramnios and
fetal distress were commonly seen in the patients, pointing towards the lack of antenatal
follow up visits due to restricted mobility in the covid era.

VITAMIN C IN TERMS OF COVID-19, CURRENT TRENDS

IlxamdjanKarimdjanov Asamovich,Nozima Sаdiqova Baxadirovna, BotirTadjiev Mirkhashimovich,NurlanDinmukhammadiev Aktamovich, BobirMirkhashimovBotirovich,YaxyayevaKomola Zokirovna,AnvarTursunbayev Karimberdiyevich,FatimaXoltayeva Fayziyevna

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 1, Pages 1341-1351

The role of vitamin C in the prevention and treatment of pneumonia andsepsis has been investigated for past decades. This reviewaimsto translatethese findings into patients with severe coronavirus disease (COVID-19). It has indicatedthat patients with pneumonia and sepsis have low vitamin C status and elevated oxidative stress.Additional oral or intravenous (IV) vitamin C administered patients with pneumonia can mitigate the severity and course ofthe disease. Severely ill patients with sepsis need for intravenous administration of amounts counted in grams ofthe vitamin to achieve adequate plasma levels, an intervention that some studies suggest reduces mortality.The vitamin has physiological functions like pleiotropic, many of which are closely connected to COVID-19.These are its antioxidant, antiinflammatory, antithrombotic and immunomodulatory functions.Previous observational studies found out low vitamin C status in critically ill patients with COVID-19.A number of randomized controlled trials (RCTs) conductedworldwideevaluate intravenous vitamin C as monotherapy in patients with COVID-19. Optimization of the intervention protocolsin future trials, e.g., earlier and continuously administration, is justified to potentially improve itsefficacy. In order to the excellent safety profile, low cost, and potential for rapid enlargement of production,administration of vitamin C to patients, especially with hypovitaminosis C and severe respiratory infections,e.g., COVID-19, appears warranted. In addition, there are few new ways of concurrent using vitamin C and other manipulations or medications.

Modern Approaches To The Selection Of Protected Cephalosporins Iii For Therapy Of Community-Acquired Pneumonia In Children

Mukhlisakhon Ravshanhanovna Kurbanova; Furkat Mukhitdinovach Shamsiev; Rano Anvarbekovna Musajavova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3008-3014

The aim of the study was to study the effectiveness of the use of protected cephalosporin III generation Extum in the treatment of community-acquired pneumonia in children. The study included 100 children with community-acquired pneumonia at the age from 1 to 15 years, who were observed and treated in the department of pulmonology. In the process of complex clinical and laboratory examination of children, biochemical, microbiological and immunological research methods were used. Microbiological studies have shown that in children with community-acquired pneumonia, S. Pneumonia occupies a significant place in the etiological structure and accounts for 42.0% of cases, a high sensitivity of pneumococcus to injectable cephalosporin of the third generation has been established. When included in complex treatment, protected cephalosporin of the third generation Extum leads to a decrease in the frequency of repeated acute respiratory infections and their complications by 2.2 times, the frequency of recurrent bronchitis and pneumonia by 1.7 times, which indicates a high therapeutic effectiveness of the proposed treatment

A Review Study On Relationship Among Covid-19 And Pneumonia

Dr.Akila K; Dr.Senthil Nathan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5476-5480

First declared as a coronavirus disease by the World Health Organisation (WHO) in March 2020 (COVID-19), the number of Positive and death cases continues to rise even seven months after that. Seven months later. This global pandemic has had a huge effect on the world's health, social and economic facets. Therefore, it is necessary to recognise the risk factors that lead to the production of serious infections for risk stratification, to improve the re-allocation of hospital resources and to direct guidelines and strategies on public health. A variety of co-morbidity consequences such as hypertension, diabetes, dyslipidemia, anaemia, coronary, thyroid disease, and pulmonary disease have been shown to be correlated with serious COVID-19 findings 1. Persons with dementia are the most fragile in normal times as they rely on others for their daily life. In a recent review, dementia has been found to increase the risk of morbidity and death, including incidence of respiratory illness, of hospitalising patients. Unfortunately, until now, no research has shown specifically how dementia is linked to COVID-19. This paper seeks to investigate the theoretically related implications of COVID-19 infection with dementia.

Out-Of-Social Pneumonia On The Background Of Chronic Kidney Disease

Lola T. Daminova; Nodirjon Z. Asadov; Davron K. Muminov

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3493-3504

Objective: to investigate the characteristics of the clinical course of community-acquired pneumonia in patients with constant kidney infection. The ponder included 120 patients with pneumonia: 40 patients had no history of renal pathology (group M), 80 patients endured from inveterate kidney infection (GFR for 3 months some time recently the improvement of pneumonia 30-60 ml / min / 1.7 m2, group M + CKD ). Confirmation of the determination was carried out on the premise of chest X-ray, the detailing of the conclusion included deciding the sort of pneumonia - croupous or central intersecting.
In a comparative evaluation of the X-ray picture within the explored groups, it was famous that in patients with pneumonia against the foundation of CKD, lobar and central intersecting pneumonia with a huge penetrate volume were altogether more frequent (p <0.001). Within the flow of follow-up, the larger part of patients (78 out of 120 patients, 65%) appeared positive clinical and radiological elements, 20 patients (16.67%) appeared no critical elements, and 22 patients (18.33%) had clinical and radiological elements. negative. Negative clinical and radiological flow was more frequently watched within the group of patients in whom pneumonia developed against the background of CKD (p <0.01).

State Of The System In Patients With Hospital Respiratory Disorder Within The Background Of Chronic Nephrosis

Botir T. Daminov; Lola T. Daminova; Nodirjon Z. Asadov; Davron K. Muminov

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3482-3492

Purpose of the study: to check some indicators of the immunohemogram in patients with community acquired respiratory disorder on the background of CKD.
Materials and methods. one hundred twenty patients with community-acquired respiratory disorder were examined: forty patients with respiratory disorder (group Pn) and eighty respiratory disorder, that developed against the background of chronic nephrosis (group Pn+ CKD). The management cluster (CG) consisted of twenty healthy individuals. The study found that the amount of leukocytes was exaggerated within the Mon + CKD cluster by 162.24% than in the CG (p <0.001), within the Mon cluster 263.14% on top of within the CG and twenty seven.79% than within the cluster Mon + CKD (p <0.001). In patients with Mon, the quantitative relation of the amount of neutrophils to lymphocytes significantly exaggerated (p <0.001 compared with the CG and also the Mon + CKD group), reflective the shift of the formula to the left, and within the Mon + CKD cluster this quantitative relation remained unchanged, despite the increase within the absolute variety of leukocytes. In patients with respiratory disorder with background CKD, a marked increase in T-lymphocytes was determined because of a population of CD8 and CD95 cells (p <0.001 compared with CG and also the Mon group). a rise in IgM concentration prevailed within the pneumonia cluster, and a rise in immune serum globulin prevailed within the PN + CKD cluster (p <0.001).
Conclusion. Respiratory disorder related to CKD is related to associate active general inflammatory response involving non-specific immunity and also the depletion of its cellular part, as well as activation of immunity because of chronic inflammation and chronic matter stimulation.

Epidemiological study of COVID-19 pneumonia in pregnant woman and their neonates; report of thirteen confirmed COVID-19 pregnant women

Alireza Kamali; Behnam Mahmodiyeh; Amir Almasi-Hashiani; Morteza Mousavi Hasanzadeh; Maryam Shokrpour

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 4455-4461

Background: In new pandemic, the probable effects of COVID-19 pneumonia on pregnant woman and their infant is one of new critical challenge for health care. Here we presented clinical symptoms, laboratory findings and outcome of COVID-19 pneumonia in pregnant woman. Methods: In a case series study, from 15 Feb to 15 June 2020, all women with RT-PCR COVID-19 who referred to two hospitals (Taleghani and Qods Hospital) affiliated to Arak University of Medical Sciences were selected. The epidemiological and demographic variables, laboratory test and outcomes obtained from patient’s medical records. Results: In this case series, we presented thirteen confirmed COVID-19 pregnant women. Their mean age was 34.6 (S.D.: 5.9) years and the mean gestational age was 32.4 (S.D.: 7.3) weeks. Most of patient didn’t show any maternal complication and intrauterine vertical transmission. The large number of pregnant women had normal HRCT and also in terms of laboratory most of the patients had normal laboratory tests. Amniotic fluids, cord blood, the throat swab of neonate in our pregnant woman with delivery were tested for COVID-19 and all of them were negative. Conclusion: The COVID-19 mothers and their infant didn’t have higher risk for morbidity and mortality and this virus didn’t associate with intrauterine vertical transmission.