Online ISSN: 2515-8260

Keywords : endogenous intoxication


Baykulov Azim; Abdullayev Davlat; Narzikulov Rustam; Oripov Rustam; Yermanov Rustam; Mamirov Vasliddin; Islamov Nurali

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 1785-1808

Background: Despite the vast experience of treating burns in surgery, a large number of victims become disabled; therefore they represent a serious medical and social problem.
Methods: The study included 120 white outbred male rats, which were simulated an experimental 3-degree topical burn and were divided into 4 groups according to the type of treatment substance. The burn was simulated by immersing the depilated skin area in boiling water. Studies of wound healing were carried out in three series, respectively, on the third, seventh and tenth days.
Results: We found that the local application of chitosan derivatives at an early stage leads to healing of the wound defect in rats in our experimental model. This was associated with a decrease in endogenous intoxication, lipoperoxidation, and internucleosomal degradation compared to the control group.
Conclusion: Thermal damage is accompanied by increased internucleosomal skin degradation. Compared with levomecol, chitosan derivatives more effectively reduce the degree of internucleosomal degradation, especially on the 10th day of the experiment.

Integrated Approaches To The Diagnosis, Treatment, And Prevention Of Stenosing Laryngotracheitis In Children

Samieva Gulnoza Utkurovna; Sobirova Shahlo Bahtiyarovna; Abdirashidova Gulnoz Ablakulovna; Pardaeva Zilola Suvankulovna

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 2722-2730

Today, acute respiratory infections, including viral ones, occupy a leading place in the pathology of childhood. One of the frequent and severe manifestations of acute respiratory diseases in young children is acute (primary and recurrent) stenosing laryngotracheitis (ASLT). The problems of acute laryngotracheitis are caused not only by its high prevalence, the possibility of severe complications and death, but also by the tendency to recurrence. No less important is the features of the formation of both acute and recurrent laryngotracheitis. In the pathogenesis of acute stenosing laryngotracheitis (OSLT) in children, one of the leading clinical manifestations is the syndrome of endogenous intoxication. These are, first of all, destructive processes, as a result of which an excessive amount of intermediate and final metabolic products accumulate in the body, which have a toxic effect on the most important life support systems.