Online ISSN: 2515-8260

Keywords : Pregabalin


Study of efficacy and safety of premedication with oral pregabalin on postoperative analgesia in parturient women undergoing elective caesarean delivery

Dr. Priyanka V, Dr. Divya Shukla, Dr. Pavan Ramachandraiah, Dr. Naziya Banu .

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 1, Pages 4546-4554

Aim: Parturient women suffer unpleasant debilitating pain, post-operatively following caesarean section. Providing adequate postoperative analgesia facilitates early ambulation, shortens hospitalization, and improves function of the mother to give better care to her New-born. Hence in our study we evaluate the effect of pre-operative single oral dose pregabalin on post-caesarean pain, cumulative analgesic consumption and its safety profile.
Materials and Methods: 60 pregnant women posted for elective caesarean section were randomised into two groups, Pregabalin group (PREGABALIN, n=30) and Placebo group (PLACEBO, n=30). The study medication was given orally with a sip of water, approximately one hour prior to expected time of the surgical incision. Hemodynamic parameters, postoperative pain score by verbal numerical rating scale (NRS), time of first rescue analgesia, cumulative maternal analgesic requirement during first 24hrs, neonatal APGAR SCORE at 1 and 5 mins were evaluated. Adverse effects due to pregabalin if any due to use of pregabalin.
Results: Time to first rescue analgesic was prolonged in Pregabalin Group as compared to Placebo Group. Mean cumulative analgesic consumption was significantly lower (p<0.0001) in Pregabalin group as compared to Placebo group. Neonatal APGAR SCORE at 1 and 5 mins were similar in both groups.
Conclusion: Pre-emptively administered single oral 150mg dose of pregabalin provides excellent postcaesarean pain relief. It also resulted in decreased analgesic requirement and less postoperative nausea and vomiting (PONV) postoperatively in parturient women.

Efficacy of pregabalin as premedication for postoperative analgesia in inguinal hernia surgery

Dr. Navveen PM, Dr. SK Srinivasan, Dr. Sittaramane S

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 3481-3487

Aim: This study is aimed to determine the efficacy of preoperative administration of oral pregabalin 150mg against the administration of a placebo for postoperative analgesia in patients undergoing Inguinal Hernia Surgery under Spinal anesthesia.
Methodology: A Prospective Randomized Double Blinded Control Study was conducted among 60 patients posted for elective Inguinal hernia surgery and were divided into equal groups. Group C received placebo and Group P received Tab. Pregabalin 150mg which was administered 30 min before surgery. Visual Analogue Score was used to determine the pain at rest during postoperative period. The time of requirement of rescue analgesia during postoperative period was also assessed.
Result: VAS at rest was significantly reduced in Group P (p<0.05). Duration of analgesia was significantly prolonged in Group P when compared to Group C (p<0.05). Time of first rescue analgesic was administered in Group Panda in Group C was noted and the mean was found to be more in the pregabalin group than in the control group (p<0.05). Rescue analgesic consumption in 24hours during postoperative period was significantly decreased in Group P (p<0.05).
Conclusion: We observed that the postoperative analgesia was definitely of a longer duration with the Group Pwhen compared to Group C and decreased requirement of parenteral analgesics in Group P. It is concluded that Tab. Pregabalin 150mg has significant postoperative analgesia when compared to placebo

Comparison ofpremedication with oral pregabalin and i.v. Dexmedetomidine on hemodynamic changes in patients undergoing laproscopic surgery

Ashok Mittal, Vivek Tyagi , Pramod Chand3, Mahesh Verma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2144-2152

Background:The major problems during laparoscopic surgery are related to the
cardiopulmonary adverse effects of pneumoperitoneum, systemic carbon dioxide absorption,
and patient positioning. Due to the requirement of steep head-up position, the chances and
severity of unwanted hemodynamic responses such as hypertension and tachycardia are much
higher in laparoscopic cholecystectomy when compared with other laparoscopic
surgeries.Objective: The goal of anesthetic management in laparoscopic surgeries is to
minimize these hemodynamic responses along with adequate depth and pain control with the
target of minimal stress response and early discharge.
Materials & Methods:The present study was conducted in MLB Medical College and
hospital, Jhansi,UP.Participants of eithersex with ASA physical status grade I & II, aged 20
to 50 years and planned for elective laparoscopic cholecystectomy under general
anaesthesiawith tracheal intubationwere included in this study.This study was carried out in
100 participants. All selected participants under study were randomely divided into two
groups depending on the premedication used.Group A patients were given i.v.
dexmedetomidine in a dose of 1ug/kg over a period of 10 minutes, diluted with 100ml normal
saline,20minutes prior to induction of anaesthesia.Group B patients were given oral
pregabalin 75 milligrams with sips of water 1.5 hour before induction. Data was analysed in
SPSS 17.0 using unpaired students t test.
Result:We found that Systolic Blood Pressure and Heart Ratewere decreased after intubation
in both the groups but fall was significantly greater in group A when compared to group B
.There was also significant fall in Mean Arterial Pressure after intubation in group A as
compared to group B.

Oral gabapentin (600mg) versus oral pregabalin (75mg) for orthopedic surgery under spinal anesthesia: Hemodynamic changes

Dr. Rahul Bankapur, Dr. Preeti Lamba, Dr. Rahul Jain

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 321-326

The myelinated A δ (sharp pain, first pain) peripheral nociceptors and unmyelinated C
nociceptors (delayed pain, second pain) respond to strong mechanical, thermal, chemical
stimuli that act as transducers, converting chemical, mechanical or thermal energy at the site
of stimulus to electrical activity, which are conducted to the dorsal horn of CNS. Based on
previous study by Usha Bafna et al., sample size was calculated to be 30 patients, to be
randomly included in each group to demonstrate a 40% difference in duration of analgesia
with a power of 0.8 and type-1 error of 0.05. To allow for study error and attrition, 35 patients
were included in each group. In Group A, 3 (8.57%) patients and in Group B, 4 (11.42%)
showed hypotension that is mean SBP was less than 20% of the base line, were as none of
patients in either group showed hypertension that is more than 20% of the baseline SBP
(intraop and postop). There was no statistically significant difference between two groups P
value (0.6903).

To study the comparison of functional outcomes between pregabalin versus gabapentin in Cases of Low Back Ache with radiculopathy

Dr.Akashdeep Singh,Dr.Saurabh Aggarwal,Dr.Tarun Behal

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1872-1875

Aims & Objectives: Millions of people have low back pain, which causes more disability
than any other health condition. The present study was planned for comparing the
functional outcomes between pregabalin versus gabapentin in Cases of Low Back Ache
with radiculopathy.
Materials & methods: A total of 100 subjects with presence of low back ache with
radiculopathy were enrolled. Clinical and MRI examination of all the patients was done.
All the 100 patients were divided into two study groups with 50 patients in each group as
follows: Gabapentin group and Pregabalin group. Capsule pregabalin 75 mg one time a
dayorally and tablet gabapentin 300 mg one timea day was given in the respective groups.
Both drugs were given at night time. Pain intensity was assessed at the start of study i.e. at
baseline (0 week), at 1 month and three months using VAS. Complications were recorded
on each visit. All the results were recorded and analysed by SPSS software.
Results: Mean VAS at baseline, one month and three months among patients of group
Pregabalin was 8.91, 6.96 and 3.16 respectively. Mean VAS at baseline, one month and
three months among patients of group Gabapentin was 8.12, 6.43 and 3.58 respectively.
While making intra-group comparison, significant results were obtained. However; while
comparing the mean VAS between the two study groups, non-significant results were
obtained at different time intervals. Sedation as a side effect was significantly more
common in Pregabalin group.
Conclusion: Gabapentin was better in comparison to pregabalin in having fewer side
effects.

Comprehensive Method For Forensic Study Of Pregabalin And Tramadol Trace Amounts Using Gas-Liquid Chromatography With Mass Spectrometric Detector And Ir-Spectrophotometry

M.U. Abdullaeva; N.Sh. Khalilova; A.Yu. Tashpulatov; Z.U. Usmanalieva

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3330-3344

Research objective: to study the possibility of using the method of chromato-mass-spectrometry combined with IR-spectrophotometry in the forensic chemical analysis of trace amounts of unknown poisonous and superpotent substances.
Material and methods. For the forensic study a material evidence – an empty glass and a used empty disposable syringe were provided by the judicial and investigation authorities, taken from the crime scene. The following tasks were set before the experts: to find traces of any substances in the glass and syringe and reveal the origin of the poisonous and superpotent substances; determine the name of the substances.
Results. During the conducted analysis using gas-liquid chromatography with the mass spectrometric detector and IR spectrophotometry, the complex method was developed for the forensic chemical examination of pregabalin and tramadol trace amounts on the object-carriers. The research established the analysis parameters such as retention time, molecular and fragmentation ions, their intensity, individual fragmentation of pregabalin and tramadol. IR spectra were obtained with characteristic passbands of functional groups related to pregabalin and tramadol structures.
Conclusion. The research proved that application of the complex methods, which have high sensitivity, speed and simplicity in use, affords to quickly and accurately identify unknown substances in the composition of micro-objects.

EVALUATION OF ORAL PREGABALIN PREMEDICATION FOR ATTENUATION OF PRESSOR RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION

Dhanshree Kale; Arachna Amol Gautam; Shraddha Naik; Avinash G. Bhosale; P. B. Patil; R. N. Mulla

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 4112-4117

A prospective, randomized study was performed after acceptance by the Ethics Committee and informed consent of 60 patients seeking elective surgery at the Krishna Hospital and the Medical Research Centre, Karad. The study objective is to evaluate haemodynamic consistency through attenuation of the pressure reaction during laryngoscopy and endotracheal intubation. Group A obtained pregabalin orally with water sips before induction and Group B served as control group, received multivitamin orally with sips of water 1hr before induction. Both groups were uniform in their distribution of age, weight and gender. They had similar physical status with no coexisting disease. Both groups were managed with same anesthetic protocol. It was concluded that the preoperative sedation before giving premedication in control and pregabalin groups are comparable, whereas pregabalin produced better preoperative sedation after one hour of premedication, as evidenced by higher Ramsay sedation score.