Online ISSN: 2515-8260

Keywords : Pregabalin


Comprehensive Method For Forensic Study Of Pregabalin And Tramadol Trace Amounts Using Gas-Liquid Chromatography With Mass Spectrometric Detector And Ir-Spectrophotometry

M.U. Abdullaeva; N.Sh. Khalilova; A.Yu. Tashpulatov; Z.U. Usmanalieva

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3330-3344

Research objective: to study the possibility of using the method of chromato-mass-spectrometry combined with IR-spectrophotometry in the forensic chemical analysis of trace amounts of unknown poisonous and superpotent substances.
Material and methods. For the forensic study a material evidence – an empty glass and a used empty disposable syringe were provided by the judicial and investigation authorities, taken from the crime scene. The following tasks were set before the experts: to find traces of any substances in the glass and syringe and reveal the origin of the poisonous and superpotent substances; determine the name of the substances.
Results. During the conducted analysis using gas-liquid chromatography with the mass spectrometric detector and IR spectrophotometry, the complex method was developed for the forensic chemical examination of pregabalin and tramadol trace amounts on the object-carriers. The research established the analysis parameters such as retention time, molecular and fragmentation ions, their intensity, individual fragmentation of pregabalin and tramadol. IR spectra were obtained with characteristic passbands of functional groups related to pregabalin and tramadol structures.
Conclusion. The research proved that application of the complex methods, which have high sensitivity, speed and simplicity in use, affords to quickly and accurately identify unknown substances in the composition of micro-objects.

EVALUATION OF ORAL PREGABALIN PREMEDICATION FOR ATTENUATION OF PRESSOR RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION

Dhanshree Kale; Arachna Amol Gautam; Shraddha Naik; Avinash G. Bhosale; P. B. Patil; R. N. Mulla

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 4112-4117

A prospective, randomized study was performed after acceptance by the Ethics Committee and informed consent of 60 patients seeking elective surgery at the Krishna Hospital and the Medical Research Centre, Karad. The study objective is to evaluate haemodynamic consistency through attenuation of the pressure reaction during laryngoscopy and endotracheal intubation. Group A obtained pregabalin orally with water sips before induction and Group B served as control group, received multivitamin orally with sips of water 1hr before induction. Both groups were uniform in their distribution of age, weight and gender. They had similar physical status with no coexisting disease. Both groups were managed with same anesthetic protocol. It was concluded that the preoperative sedation before giving premedication in control and pregabalin groups are comparable, whereas pregabalin produced better preoperative sedation after one hour of premedication, as evidenced by higher Ramsay sedation score.