FORMULATION AND CHARACTERIZATION OF MUPIROCIN GEL AND EVALUATION OF IN VITRO ANTIMICROBIAL ACTIVITY AGAINST STAPHYLOCOCCUS AUREUS
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 11, Pages 7491-7501
AbstractMupirocin is a broad-spectrum antimicrobial agent available as ointment, and creamin the market.
However, the present investigation aims to formulate Mupirocin gel for topical application for convenient drug delivery. Gels are non-greasy and sustained release formulations possessing better adherence properties. Carbopol 934P was taken as gelling agent for the formulation of gel. The prepared gel was evaluated for its physical appearance, texture, pH, viscosity, spreadabilityand in-vitro performance.A stability study of prepared gel was performed.The formulated gel was compared with marketed Mupirocin ointment Bactroban (brand name)and was found to be effective than marketed preparation.
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