LIPID NANOGEL FOR TRANSDERMAL DELIVERY OF LOVASTATIN : IN VITRO CHARACTERIZATION
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 10, Pages 3839-3848
AbstractLipid nanogel was fabricated by incorporating lovastatin loaded solid lipid nanoparticles in carbopol 934P.Lovastatin loaded Solid lipid nanoparticles were prepared by solvent emulsification diffusion technique by using Glyceryl behanate as lipid. The prepared SLNs in the form of nanosuspension were evaluated for Zeta potential, Particle size, Polydispersity index, and percent drug entrapment efficiency. Carbopol 934P was added to the nanosuspension to prepare nanogel. The nanogels were evaluated for physical appearance, pH, viscosity, spreadabilityandinvitro release profile. Gel formulation was also evaluated for stability.The results indicate that the SLNs have an average particle size of 370 ± 3.67 nm with 0.43 ± 0.12 PDI and -18.8 ± 2.41 MeVzeta potential.The percent drug entrapment was 90.0%. The optimized gel was clear,homogeneous,and have neutral pH near to 7.The viscosity and spreadability of formulated gel were 99054 ± 97.38 centipoise and 18 ± 2.3 mm, respectively. the release from gel was98.6±1.32 and following Higuchi’s kinetics. The formulation was stable up to a period of three months.
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