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  2. Volume 8, Issue 3
  3. Authors

Online ISSN: 2515-8260

Volume8, Issue3

Study of skin expression of thrombomodulin in the Psoriatic Plaques

    May mostafa Abo Al-kher MSc Sawsan Khalifa Elsayed M.D Safinaz Salah Eldin Sayed M.D Sara Ahmed Galal M.D

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 1625-1637

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Abstract

Background: Psoriasis is a chronic relapsing, immune-mediated inflammatoryskin disease of unknown etiology. The role of thrombomodulin (TM) in different autoimmune inflammatory diseases was explored previously in some studies. Thus; the aim of this study was to assess TM expression in the affected skin of patients with psoriasis.
Methods: This prospective case-control study was carried out on 30 patients with chronic plaque psoriasis and 30 age and gender matched apparently normal subjects as a control group. Skin biopsies were taken for immunohistochemical evaluation of TM expression.
Results: There was a highly significant difference between the two studied groups regarding the expression of TM in the skin. Patients group had a higher expression of TM in both epidermis and dermis compared to controls with a highly statistically significant difference, P-value< 0.01.
Keywords:
    psoriasis Immunohistochemistry Thrombomodulin
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(2021). Study of skin expression of thrombomodulin in the Psoriatic Plaques. European Journal of Molecular & Clinical Medicine, 8(3), 1625-1637.
May mostafa Abo Al-kher MSc; Sawsan Khalifa Elsayed M.D; Safinaz Salah Eldin Sayed M.D; Sara Ahmed Galal M.D. "Study of skin expression of thrombomodulin in the Psoriatic Plaques". European Journal of Molecular & Clinical Medicine, 8, 3, 2021, 1625-1637.
(2021). 'Study of skin expression of thrombomodulin in the Psoriatic Plaques', European Journal of Molecular & Clinical Medicine, 8(3), pp. 1625-1637.
Study of skin expression of thrombomodulin in the Psoriatic Plaques. European Journal of Molecular & Clinical Medicine, 2021; 8(3): 1625-1637.
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