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  2. Volume 8, Issue 3
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Online ISSN: 2515-8260

Volume8, Issue3

The ability of astaxanthin-rich Haematococcus pluvialis algal extract on preventing harmful effects of H2O2 on human fibroblast cells in vitro

    Quan Minh To Dieu Quang Tran Tuyet Thi Vy Le Ha Le Bao Tran Long Thanh Le

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 1809-1819

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Abstract

This study aimed to determine the ability of astaxanthin-rich Haematococcus pluvialis algal extract (AE) on preventing adverse effects of H2O2 on human skin fibroblast cells. A Haematococcus pluvialis strain obtained from Vietnam was used as a source of astaxanthin. hF cells were cultured in DMEM/F12 medium supplemented with AE 0, 10, 25, 50 μg/ml for 7 days. WST-1 assay results showed that AE 10-50 μg/ml was not poisonous and didn’t have any negative effects on cell proliferation. hF cells were pre-treated with AE (0, 10, 25, 50 μg/ml) for 24 hours prior to H2O2 treatment (200 μM, 120 minutes). The results showed that AE protected hF cells: reduction of G0/G1 phase cells in cell populations (16.08 – 21.52%), senescence-associated β-galactosidase – positive cells (28.9 – 40.8%), and maintenance of cell proliferation, nuclear area. AE 10 μg/ml is the optimal concentration in this study. In conclusion, AE has been shown to have the ability to protect fibroblasts from the adverse effects of H2O2.
Keywords:
    Astaxanthin Haematococcus pluvialis cell senescence skin aging hydrogen peroxide
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(2021). The ability of astaxanthin-rich Haematococcus pluvialis algal extract on preventing harmful effects of H2O2 on human fibroblast cells in vitro. European Journal of Molecular & Clinical Medicine, 8(3), 1809-1819.
Quan Minh To; Dieu Quang Tran; Tuyet Thi Vy Le; Ha Le Bao Tran; Long Thanh Le. "The ability of astaxanthin-rich Haematococcus pluvialis algal extract on preventing harmful effects of H2O2 on human fibroblast cells in vitro". European Journal of Molecular & Clinical Medicine, 8, 3, 2021, 1809-1819.
(2021). 'The ability of astaxanthin-rich Haematococcus pluvialis algal extract on preventing harmful effects of H2O2 on human fibroblast cells in vitro', European Journal of Molecular & Clinical Medicine, 8(3), pp. 1809-1819.
The ability of astaxanthin-rich Haematococcus pluvialis algal extract on preventing harmful effects of H2O2 on human fibroblast cells in vitro. European Journal of Molecular & Clinical Medicine, 2021; 8(3): 1809-1819.
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