Role of Autophagy in Psoriasis
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 3, Pages 1963-1978
AbstractAutophagy is a complicated cellular mechanism that maintains cellular and tissue homeostasis and integrity via degradation of senescent, defective subcellular organelles, infectious agents, and misfolded proteins. Accumulating evidence has shown that autophagy is involved in numerous immune processes, such as removal of intracellular bacteria, cytokine production, auto antigen presentation, and survival of lymphocytes, indicating an apparent and important role in innate and adaptive immune responses. Current studies indicate that autophagy is important for the regulation of inflammation through disruption of multiple steps of inflammasome activation, therefore preventing inflammation.
Psoriasis is a chronic immune-mediated inflammatory skin disease that affects approximately 2% of the population worldwide. Importantly, studies have shown that constitutive granular layer autophagy is deregulated in psoriasis patients. Moreover, autophagy could down regulate pro-inflammatory cytokine production, exert a protective role in inflammatory diseases, and clear cellular materials such as damaged mitochondria to maintain cellular homeostasis; all these effects play a supporting role in the protection against inflammation associated skin diseases. In psoriasis, autophagy may reduce inflammation and proliferation of keratinocytes and may also promote bacterial clearance.hemistepsin A, lupiwighteone may be promising therapeutic targets in psoriasis treatment
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