ANTIPROLIFERATIVE ACTIVITY OF COCCINIA GRANDIS AGAINST CANCER CELL LINES
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 10, Pages 3895-3900
AbstractCancer is the most devastating diseases, having significant social and economic impacts on the health care system and second leading cause of death in both men and women worldwide[1,2,3,]. Cancer can be characterized by the failure in the regulation of tissue growth results in the uncontrolled multiplication of the normal cells to form tumors which in further invades into nearby parts of the body . It is estimated that every year, 10 million people are diagnosed with cancer, and of these, 6 million was die of this disease .
Treatment to cancer has being researched on a large scale however, resistance to anticancer drugs has also been observed. Therefore, natural products from plants play a dominant role in the discovery of such new drugs. It has been estimated that about 60% of approved drugs were of natural origin . Over 50% of drugs used in clinical trials for anticancer activity were isolated from natural sources or are related to them . Hence, the search for natural products to be used in cancer therapy represents an area of great interest in which the plant kingdom has been the most important source, providing many anti-tumor agents with novel structures and unique mechanism of action .
Many substances derived from dietary or medicinal plant known to be effective and versatile chemo preventive and antitumor agents in a number of experimental models of carcinogenesis. The cytotoxicity of plant material is considered to be due to the presence of antitumor compounds .
Coccinia grandis is one of the many vegetables that reduce the risk of cancer. The anticancer activity of the Coccinia grandis may be due it’s the antioxidant nature. Nitric oxide is a free radical which acting an important role in the pathogenesis of pain and inflammation. The antioxidant principle of Coccinia grandis decreases the nitrite generated by decomposition. Coccinia grandis significantly reduced viable cell count and increased non-viable cell count suggesting comparable anticancer property with that of the reference drug (vinblastine) .
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