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  2. Volume 7, Issue 11
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Online ISSN: 2515-8260

Volume7, Issue11

HEPATOPROTECTIVE EFFECT OF d-LIMONENE AGAINST ADRIAMYCIN INDUCED HEPATOTOXICITY IN EXPERIMENTAL RATS

    Dr. IndumathiSelvanathan Dr.Sivasakthi Arumugham S.M.Fazeela Mahaboob Begum

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 7712-7721

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Abstract

Objective: Monoterpenes plays an essential role to fight against various diseases. Among the various monoterpenes an efficientd-Limonene plays a fundamental role to fight against hepatotoxicity caused by cancer chemotheraphy treatment. Hence the presence study is to evaluate hepatoprotective function of d-limonene against adraimycin induced hepatotoxicity.
Methods: Male albino Wistar rats were administrated with ADR (15mg/Kg body weight) in six equal injection, and the protection efficacy of d-limonene (100mg/Kg body weight) was examined with reference to tissue AST level and the pathological studies was examined by microscopic study.
Results: Rats treated with ADR results in elevated level of liver AST marker enzymes, whereasthe level of AST was controlled when administrated with d-Limonene. However Histopathological proof added more protective role of rats treated with d-limonene against hepatotoxicity.
Conclusion:ADR administration of 15mg/Kg body weight of rats increase the level of hepatotoxicity by increasing the marker enzyme activity and show severe morphological changes. The final outcome from our result suggests that d-limonene (100mg/Kg body weight) a vibrant monoterpene act as latent hepatoprotective negotiator by attenuating ADR induced hepatotoxicity
Keywords:
    Adriamycin d-limonene AST Histopathology Hepatotoxicity
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(2021). HEPATOPROTECTIVE EFFECT OF d-LIMONENE AGAINST ADRIAMYCIN INDUCED HEPATOTOXICITY IN EXPERIMENTAL RATS. European Journal of Molecular & Clinical Medicine, 7(11), 7712-7721.
Dr. IndumathiSelvanathan; Dr.Sivasakthi Arumugham; S.M.Fazeela Mahaboob Begum. "HEPATOPROTECTIVE EFFECT OF d-LIMONENE AGAINST ADRIAMYCIN INDUCED HEPATOTOXICITY IN EXPERIMENTAL RATS". European Journal of Molecular & Clinical Medicine, 7, 11, 2021, 7712-7721.
(2021). 'HEPATOPROTECTIVE EFFECT OF d-LIMONENE AGAINST ADRIAMYCIN INDUCED HEPATOTOXICITY IN EXPERIMENTAL RATS', European Journal of Molecular & Clinical Medicine, 7(11), pp. 7712-7721.
HEPATOPROTECTIVE EFFECT OF d-LIMONENE AGAINST ADRIAMYCIN INDUCED HEPATOTOXICITY IN EXPERIMENTAL RATS. European Journal of Molecular & Clinical Medicine, 2021; 7(11): 7712-7721.
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