European Journal of Molecular & Clinical Medicine

Abstract

The purpose of the present study was to investigate whether the ADIPOQ +276 G>T (rs1501299) and –11377 G>C (rs266729) polymorphisms, would influence the effect of a 8-week Combined Training program. After the pre-test, 30 obese boys (BMIZ>+2), aged 11-13 (12.66±0.47) participated in the combined training protocol for 3 sessions per week for 2 months. DNA was extracted from cheek cells donated by the 30 participants and genotyping was carried out using PCR. Our results suggest that the ADIPOQ genotypes can modulate training-induced body mass measurement changes: After the training program, carriers of rs266729 C allele were characterized by a greater reduction in Fat Mass Percentage (FM), BMIZ, WHR and carriers of rs1501299 G and T by a greater reduction in Body Mass, BMIZ and Fat Mass Percentage and WHR, respectively. Moreover, the ADIPOQ polymorphisms were associated with changes in lipid profile and Adiponectin hormone in response to training. Additionally, we showed two main effects of genotypes (rs266729) for the cholesterol and adiponectin in response to training. From this evidence, it could be concluded that rs266728 G variants may be considered as a disadvantageous factor in the context of training-induced effects on body mass traits in obese boys