Gene Therapy of Cystic Fibrosis Using Influenza Virus
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 1, Pages 2123-2129
AbstractCystic fibrosis is a genetic disease due to a mutation in a gene encoding the cystic fibrosis transmembrane conductance regulator chloride channel. In this proposed method, by genetically manipulating the gene structure in the influenza virus and inserting this manipulated gene into the body, we force the cell to produce a healthy version of the CFTR gene. The influenza virus belongs to the family Orthomyxoviridae and enters the body through SAA2,6Gal receptors in epithelial cells (1). If we genetically modify the related gene in the influenza virus and insert the CFTR gene, the influenza virus, which has been modified by gene therapy, can force the infected cell to express the healthy CFTR gene mRNA. Based on this method, it seems that the cause of this disease, which is the absence of CFTR proteins on the patient's cell surface, can be alleviated to some extent by inserting the healthy transcript of CFTR into the membrane phospholipids.
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