European Journal of Molecular & Clinical Medicine

Abstract

A novel series of substituted pyrazolopyrimidine derivatives have been synthesized from
substituted hydrazine derivatives and ethoxy (methylene) malanonitrile gives an
intermediate (5-amino-1- substituted phenyl pyrazole-4-carbonitrile) (1) which on further
react with formic acid, acetic acid/HCl and formamide gives series of (1-
substitutedphenyl)1H pyrazole [3,4-d] pyrimidine-4(5H)-one (2). The synthesized
compounds were characterized on the basis of IR, 1H NMR and Mass spectral data.
Furthermore, these newly synthesized compounds were screened for their antioxidant
activity by DPPH free radical scavenging method. Unfortunately none of the compound
shows antioxidant activity.