To determine the role of injection Iron Sucrose for the treatment of iron deficiency anemia in pregnancy: A prospective observational study
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 11, Pages 8007-8012
AbstractAim: The aim of the present study was to determine the efficacy of injection Iron Sucrose for the treatment of iron deficiency anemia in pregnancies that were given iron sucrose for non-compliance or intolerance to oral iron.
Material and methods: A prospective, observational study was conducted in the Department of Obstetrics & Gynaecology, NSMCH, Bihta, Patna, Bihar, India, for 10 months. Total 100 patients were included in the study. They were chosen to be given injection Iron Sucrose on the basis of intolerance or non-compliance to oral iron therapy or were deemed suitable by the clinician to be given iron sucrose and after confirmation of iron deficiency. All the patients were in their third trimester. Doses were calculated as per Ganzoni’s formula mentioned below and various maternal outcomes were studied. Hemoglobin was checked after 6 weeks and before delivery. Serum ferritin was also checked before initiating the treatment and also at term. All women attending antenatal clinic with hemoglobin >7.5 gm% and <11 gm% in third trimester were included in this study.
Results: Most of our patients were aged between 20 and 30 years (74%). Primigravidae and multigravidae were almost equal in number (47% and 53% respectively) enrolled in the study. The study population had co morbidities like gestational diabetes mellitus, gestational hypertension, history of previous cesarean and thyroid disorders and all of them were stable on medication. Haemoglobin from before treatment (mean 9.74±0.854 gm%) to after treatment (mean 10.89±0.764 gm%) was statistically significant (p-value <0.001) with mean increase in haemoglobin of 11.07% 6 weeks after treatment. Haemoglobin rise at term (mean 10.99±0.641 gm%) was also significant (p-value <0.001) with mean increase in haemoglobin of 11.82% at term. Rise in ferritin levels from before treatment (mean 27.21 ng/mL±13.12) to ferritin levels at term (mean 66.21 ng/mL±14.89) was also significant (p-value <0.001) with mean increase in serum ferritin level of 60.11% at term.
Conclusion: The iron sucrose is an excellent option to treat iron deficiency anemia in patients where oral iron therapy has either failed or not suitable. It significantly increases hemoglobin levels in the study population. It is readily available in the market and can be infused on an outpatient basis.
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