Hyperhomocysteinemia in pregnancy induced hypertension: a case-control study
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 8, Pages 5711-5716
AbstractAim: To study the Hyperhomocysteinemialevels in pregnancy induced hypertension. Materials and Methods: A Case control study was conducted in the Department of Obstetrics & Gynaecology, NSMCH, Bihta, Patna, Bihar, India, for 1 year. Total 240 pregnant female subjects in the age group of 16-55 yrs was selected. Out of them 120 were normotensive pregnant women (NPW) in their third trimester and were chosen as control Group 1 and 120 pregnancy induced hypertensive (PIH) patients in their third trimester were chosen as study Group 2.
Results: The hypertensive subjects had similar age distributions and values of BMI when compared to normotensive controls. The percentage of subjects who were smokers was not different between the two groups. Although most of the hypertensive patients were receiving antihypertensive treatment, their systolic and diastolic blood pressure were significantly higher than those of the normotensive individuals. The mean and standard deviation of Homocysteine, uric acid and magnesium levels of NPW and PIH groups. The Hcy level was significantly increased with a mean and standard deviation (SD) value of 20.77±5.95µmol/l (p- value=0.001) and the uric acid level was also increased with a mean and SD of 6.15±0.77mg/dl (p-value= 0.002) in the PIH. The Hcy level was 9.12 ± 2.33µmol/land the Uric acid level was 3.17 ± 0.82mg/dl in NPW group. . The magnesium level was lower in the PIH compared to NPW (p - value=0.001).
Conclusion: The Hcy and uric acid levels were increased and Magnesium level was decreased in PIH women than the NPW. So these parameters should be part of the evaluation of the pregnant women presenting with hypertension. Thereby, we can reduce the maternal and fetal mortality rate.
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