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  2. Volume 2, Issue 2
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Online ISSN: 2515-8260

Volume2, Issue2

TCR gene therapy of leukemia

    Shao-An Xue

European Journal of Molecular & Clinical Medicine, 2015, Volume 2, Issue 2, Pages -

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Abstract

Conventional cancer therapies are limited by their toxicity and lack of specificity. To achieve targeted immunotherapy of cancer, we have chosen Wilm's Tumour antigen (WT1) as a target as it is over-expressed in most leukemia and many solid cancers. Using sophisticated WT1-TCR retroviral constructs, we have performed in vivo engraftment studies with CD34+ leukemic progenitor cells. In our model, treatment with WT1-TCR engineered patiens' T cells had cleared patients own leukemic cells. As the analysis of bone marrow indicated that control group showed evident engraftment of human leukemia cells, while the WT1-TCR treated group had none detectable.
Keywords:
    These data have provided a solid basis for a phase I/II clinical trial demonstrating that WT1
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(2015). TCR gene therapy of leukemia. European Journal of Molecular & Clinical Medicine, 2(2), -.
Shao-An Xue. "TCR gene therapy of leukemia". European Journal of Molecular & Clinical Medicine, 2, 2, 2015, -.
(2015). 'TCR gene therapy of leukemia', European Journal of Molecular & Clinical Medicine, 2(2), pp. -.
TCR gene therapy of leukemia. European Journal of Molecular & Clinical Medicine, 2015; 2(2): -.
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