Acute Dermal Toxicity study of Rasapushpadi Malhara & It’s Modified Dosage forms
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 3, Pages 2543-2549
Abstract
Rasapushpadi Malahara is one such preparation mentioned in Rasa tarangin icontaining ingredients like parada, saindhava, kasisa and siktha taila having indications like phiranga, vicharchika ,vrana etc. In the present study The Rasapushpadi Malhara prepared by classical method and its modified dosage forms cream and lotion prepared by using chemicals as per modern text.Material and methods:
Acute dermal toxicity study was carried out as per OECD 402. Wistar albino rats of female sex were used in the experimentation. The rats were obtained from animal house of DMIMS Wardha (MH), The experimental protocols were approved by Institutional Animal Ethics Committee ( DMIMS (DU) /IAEC/2018-19/08 ).
Results and discussion:
Dermal toxicity study results showed weight of all animals of control & test groups was slightly increased or decreased. All animals were found active and healthy no any changes in behavior and activity was observed. All Heamatological perameters, Biochemical perameters and Histopathological perameters was normal in range
Conclusion
The Results of this study shows Nontoxic effects of Rasapushpadi Malahara and its modified dosage forms ( Cream & Lotion). All observed perameters like body weight , cage side observations , DDISS, Heamatologicalperameters, Biochemical perameters and Histopathological perameters was normal in range.
Key words :Rasapushpadi Malahara , Dermal Toxicity, OECD 402 .
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