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  2. Volume 2, Issue 2
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Online ISSN: 2515-8260

Volume2, Issue2

Anti-tumor effects of the human monoclonal antinuclear antibody on the HEp-2 cells

    Fengmin Zhang Yujun Li Yong Fang Wenping Kao Wuqi Song

European Journal of Molecular & Clinical Medicine, 2015, Volume 2, Issue 2, Pages -

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Abstract

Function of autoantibodies from patients with autoimmune diseases in malignancies development is not clear yet. It has been reported that a cell-penetrating lupus autoantibody, 3E10, which was isolated from a mouse model of systemic lupus erythematosus (SLE), has been a potential targeted therapy for DNA-repair deficient malignancies. We have got four human monoclonal antinuclear antibodies from patients with autoimmune disease, 3B5, 3C1, 3E8 and 4F3. Our data showed that four antibodies could combine HEp-2 cells and display different nuclear types as antinuclear antibody (ANA). Also, these four ANAs can inhibit HEp-2 cells proliferation. We think these antibodies may be potential antibody drugs to cancer therapy. However, the function and mechanism are not clear. Further study, we want to clarify the effects of four ANAs on proliferation of various cancers cells and to investigate the mechanism of four ANAs affecting various cancers cells proliferation and their targets.
Keywords:
    This may be a new mechanism of malignancies development in patients with autoimmune diseases and provide novel angle of autoantibody function study
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(2015). Anti-tumor effects of the human monoclonal antinuclear antibody on the HEp-2 cells. European Journal of Molecular & Clinical Medicine, 2(2), -.
Fengmin Zhang; Yujun Li; Yong Fang; Wenping Kao; Wuqi Song. "Anti-tumor effects of the human monoclonal antinuclear antibody on the HEp-2 cells". European Journal of Molecular & Clinical Medicine, 2, 2, 2015, -.
(2015). 'Anti-tumor effects of the human monoclonal antinuclear antibody on the HEp-2 cells', European Journal of Molecular & Clinical Medicine, 2(2), pp. -.
Anti-tumor effects of the human monoclonal antinuclear antibody on the HEp-2 cells. European Journal of Molecular & Clinical Medicine, 2015; 2(2): -.
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