A Retrospective Study on Carcinoma of Breast in Young Females
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 10, Pages 4099-4104
Breast cancer is the most common cancer in women and the second most common cancer worldwide. It is also the second leading cause of death due to cancer. Breast cancer is less frequent in the younger age group but have a poorer outcome in contrast to the breast cancer arising in the older age groups. There is a lack of awareness and due to this, majority of patients present late. The aim of this study is to know the incidence and clinicopathological features of breast cancer in young females under the age of 40 years.
Methods: This is a retrospective study done over a period of one year (2018) at ESI medical college and hospital, Kalaburagi, Karnataka. The hospital and lab records were searched for histologically confirmed breast cancer cases in female patients under the age of 40 years. A total of 14 breast cancer cases were identified and hematoxylin and eosin stained histopathology slides were retrieved from the histopathology archives and were reviewed. The available slides of immunohistochemistry markers were also reviewed.
Results: The most common histological type was infiltrating ductal carcinoma (IDC) seen in 13 (92.8%) cases with 1 case of invasive lobular carcinoma. Half of cases were of stage III at the time of diagnosis. 4 (28.57%) cases presented as stage II and 3 (21.4%) cases were stage I. There was a predominance of higher grade with 7 (50%) cases having grade II and 5 (35.7%) of cases were grade III. On IHC, 4 cases (28.57%) were negative for estrogen receptor, progesterone receptor and Her 2 neu
Conclusion: Young breast cancer patients present with higher stage, higher tumor grade and hormonal receptor negative status. More studies are needed to investigate survival and post treatment recurrence in young females with breast cancer.
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