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  2. Volume 2, Issue 4
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Online ISSN: 2515-8260

Volume2, Issue4

Transcriptome markers of viral persistence in naturally-infected Andes Hantavirus (Bunyaviridae) seropositive rice rats

    Corey L. Campbell Fernando Torres-Perez Mariana AcunaRetamar Tony Schountz

European Journal of Molecular & Clinical Medicine, 2015, Volume 2, Issue 4, Pages 132-133

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Abstract

The long-tailed pygmy rice rat (Oligoryzomys longicaudatus) is the reservoir host of Andes (ANDV) and Oran hantaviruses (Bunyaviridae). To examine transcriptome features of persistently infected rice rats, spleens from ANDV sero-positive wild-caught rice rats were assessed. RNA-seq analysis, de novo reference-independent assembly and stringent orthology assignments produced 17,756 unique coding and non-coding RNAs. Differential expression analysis of persistently-infected seropositive rice rat spleens revealed 18 differentially expressed transcripts from 16 unique genes. A three-pronged effect on the immune response were observed in 1) suppression of the JAK-STAT pathway at Stat5b and Ccnot1, as well as 2) a bias toward a TH2 response in the enrichment of caspase-1 and 3) stimulation of RIG-I pathway factors Ppp1cc and MFF. Two of these differentially expressed transcripts, caspase-1 and STAT5b, code for proteins expected to stimulate T helper follicular (TFH) cell development, a phenomenon that has also been described for hantavirus-infected P. maniculatus. Differential expression of a single seropositive rice rat with a higher viral load revealed a robust response of 243 differentially expressed transcripts, suggesting an acute infection.
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(2015). Transcriptome markers of viral persistence in naturally-infected Andes Hantavirus (Bunyaviridae) seropositive rice rats. European Journal of Molecular & Clinical Medicine, 2(4), 132-133.
Corey L. Campbell; Fernando Torres-Perez; Mariana AcunaRetamar; Tony Schountz. "Transcriptome markers of viral persistence in naturally-infected Andes Hantavirus (Bunyaviridae) seropositive rice rats". European Journal of Molecular & Clinical Medicine, 2, 4, 2015, 132-133.
(2015). 'Transcriptome markers of viral persistence in naturally-infected Andes Hantavirus (Bunyaviridae) seropositive rice rats', European Journal of Molecular & Clinical Medicine, 2(4), pp. 132-133.
Transcriptome markers of viral persistence in naturally-infected Andes Hantavirus (Bunyaviridae) seropositive rice rats. European Journal of Molecular & Clinical Medicine, 2015; 2(4): 132-133.
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