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  2. Volume 8, Issue 3
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Online ISSN: 2515-8260

Volume8, Issue3

EVALUATION OF SERUM MIRNA-217 AND MIRNA-143-3P AS POTENTIAL BIOMARKERS FOR ESOPHAGEAL ACHALASIA

    Mahin Gholipour Javad Mikaeli Seyed Javad Mowla Marie Saghaeian Jazi Narges Fazlollahi Masoud Khoshnia Abdolvahab Moradi

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3102-3108

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Abstract

The use of a low-risk and convenient diagnostic method is important in the early diagnosis of achalasia and could prevent the side effect of delay in initiation of treatment. According to our previous NGS study, two miRNAs, hsa-miR-217 and hsa-miR-143-3p were differentially expressed in achalasia esophageal tissue. The present study aimed to assess two microRNAs, hsa-miR-217 and hsa-miR-143-3p as serum biomarkers for early detection of achalasia. Serum was collected from patients with achalasia and non-achalasia participants. The relative expression of hsa-miR-217 and hsa-miR-143-3p were determined using quantitative real-time polymerase chain reaction. The expression of hsa-miR-217 was different in the serum of patients with achalasia and controls, but this difference was not significant (p-value = 0.572). Besides, the results showed that the serum expression of miRNA-143-3p was not significantly different between the patients with achalasia and the control group (p-value = 0.366). Our findings could not support serum miRNA-217 and miRNA-143-3p as potential diagnostic biomarkers for achalasia.
Keywords:
    Achalasia biomarker microRNA miRNA-217 miRNA-143-3p
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(2021). EVALUATION OF SERUM MIRNA-217 AND MIRNA-143-3P AS POTENTIAL BIOMARKERS FOR ESOPHAGEAL ACHALASIA. European Journal of Molecular & Clinical Medicine, 8(3), 3102-3108.
Mahin Gholipour; Javad Mikaeli; Seyed Javad Mowla; Marie Saghaeian Jazi; Narges Fazlollahi; Masoud Khoshnia; Abdolvahab Moradi. "EVALUATION OF SERUM MIRNA-217 AND MIRNA-143-3P AS POTENTIAL BIOMARKERS FOR ESOPHAGEAL ACHALASIA". European Journal of Molecular & Clinical Medicine, 8, 3, 2021, 3102-3108.
(2021). 'EVALUATION OF SERUM MIRNA-217 AND MIRNA-143-3P AS POTENTIAL BIOMARKERS FOR ESOPHAGEAL ACHALASIA', European Journal of Molecular & Clinical Medicine, 8(3), pp. 3102-3108.
EVALUATION OF SERUM MIRNA-217 AND MIRNA-143-3P AS POTENTIAL BIOMARKERS FOR ESOPHAGEAL ACHALASIA. European Journal of Molecular & Clinical Medicine, 2021; 8(3): 3102-3108.
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