Assessment of Prognostic markers of Diabetic Nephropathy- Serum Creatinine and Blood Urea Levels in Diabetes mellitus and healthy individuals at tertiary care hospital
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 11, Pages 8499-8505
AbstractIntroduction: Diabetes being a chronic progressive disorder severely affecting the end organs like nerves, eyes and kidneys. Hence, diabetic patients are at an increased risk of developing specific complications like nephropathy, retinopathy, neuropathy, and atherosclerosis. Diabetic nephropathy occurs in approximately one third of Type 2 diabetic patients. In diabetic nephropathy, a number of serum markers are deranged. Out of which, plasma creatinine and urea are early indicators of disease progression leading to complications. The morbidity and mortality caused by diabetes mellitus can be reduced by regular screening, early detection, and appropriate treatment of chronic complications. Plasma creatinine and urea are useful clinical tools in assessing renal function.
Objectives: This study is undertaken to measure blood glucose, serum creatinine and blood urea levels in Type 2 diabetic patients and to compare it with non-diabetic subjects. This study aims to signify the role of measuring filtration markers i.e. plasma creatinine and urea levels in assessing renal function.
Material and method: A cross sectional study was done from September 2019 to December 2019. This study included 50 known cases of type II diabetes mellitus attending diabetic Out Patient Department at Sarojini Naidu medical college, Agra of age 40-60 years with duration of 5-10 years and 50 non diabetic healthy controls fulfilling the inclusion criteria.
Biochemical investigations included fasting blood glucose, serum creatinine and blood urea. Statistical analysis was done by using SPSS Software.
Observation and results: The mean values of blood glucose levels (fasting and postprandial) in Group 1and Group 2 were 140.5±64.98 and 88.58 ±7.64 and 170.05± 65.83 and 123 .67± 9.25 respectively. Serum creatinine levels in Group 1and Group 2 were 1.68±0.44 and 0.88 ±0.11 and blood urea levels in Group 1and Group 2 were 41.56±6.60 and 29.7±6.09 respectively.
There was a significant increase in blood glucose concentrations, plasma creatinine and urea concentrations in diabetic patients when compared to non diabetic subjects.
Conclusion: The study concluded that in addition to increased blood glucose level in Type 2 diabetes mellitus, plasma creatinine and urea concentration are also significantly increased when compared with non diabetic subjects.
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