EVALUATION OF URIC ACID & pH LEVEL IN SALIVA BEFORE AND AFTER COMPLETE DENTURE WEARING: AN IN VIVO STUDY
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 11, Pages 8506-8515
AbstractAn in-vivo study was conducted to evaluate uric acid & pH level in saliva before and after complete denture wearing. 100 completely edentulous patients (between 40-80-year ages) for the clinical study are taken. The test subject 100 in number was divided into two groups of 50 each and each group was further divided into two groups of 25 each. Group A (age between 40-60 years) contains two subgroups: group A1 for smokers and group A2 for nonsmokers. Group B (age between 61-80 years) contains two subgroups: group B1 for smokers and group B2 for nonsmokers. Saliva samples were collected from subjects immediately before the insertion of dentures. Subjects were recalled one month after the denture insertion for collecting their second set of saliva samples. Saliva of first container was used in pH estimation. Saliva of second container was used in uric acid estimation. pH estimation is carried out using digital pH meter & uric acid estimation is done by Semi-automated clinical chemistry analyzer (Micro Lab 300, Merck, Germany). It was found that salivary uric acid and pH was significantly decreased after one month of denture insertion. Effect of age on pH is not significantly decreased but effect of age on uric acid is significantly decreased. Effect of smoking on pH and uric acid is slightly higher significant as compared to nonsmokers. Some remedies are suggested to minimize this problem.
Key words: Potential of hydrogen (pH), Oxidative Stress (OS), Superoxide Dismutase (SOD), Reactive oxygen species (ROS)
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