IN VIVO DEPOSITION AND INHALATION TOXICITY OF CEFDINIR LOADED FUNCTIONALIZED CARBON NANOTUBES AS NOVEL APPROACH OF FORMULATION OF RESPIRABLE PARTICLE.
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 3, Pages 3378-3392
Abstract
A dry-powder inhaler (DPI) is a device that delivers medication to the lungs in the form of a dry powder which are commonly used to treat respiratory diseases. Present work was attempted to investigate the potentialities of Multi-walled carbon nanotubes (MWCNT) as a pulmonary carrier for targeting Cefdinir tolung infection. Functionalization of MWCNTs by reported method and loaded with Cefdinir using the Incipient Wetness impregnation method to formulate Cefdinir loaded respirable particle(CLRP) which has efficient treatment against lung infections.This is evaluated by particle size, flow properties in vitro release kinetics, in vivo deposition study, acute inhalation toxicity study and Ex-vivo antimicrobial study. The results indicated that CLRP are nontoxic and 95% entrapment with better flow properties was achieved. The optimized formulation had particle size is6.482±0.09 μm. The release pattern of CLRP was shown to release in a controlled manner for 24 hours (i.e. after 24 hours it was 88 %). In vivo lung deposition study showed that maximum amount of drug is present in lung. Formulated respirable particle show better antimicrobial activity against gram (+ve) andgram (-ve). This work established a novel, easy to prepare with better drug loading efficiency.Keywords: Respirable, Cefdinir, Deposition, Functionalization, Wetness Impregnation Method.
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