A retrospective study to assess penial development in response to hormone therapy in children diagnosed with micropenis
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 11, Pages 8626-8631
Aim: To evaluate the penial growth in response to hormone treatment in children with micropenis.
Methods: This retrospective study which was carried in the Department of General surgery, Government medical College, and Hospital Bettiah, Bihar, India for 1 year. 50 children (<18 years) who met the criteria for micropenis were included in this study. Children more than 10 years old (pubertal/post pubertal) were treated using a standard protocol of 1,500 to 2,000 IU hCG administrated intramuscularly, once per week, for 6 weeks, whereas children less than 10 years old (prepubertal) were treated with parenteral testosterone enanthate 25 mg once a month for 3 months. Measurement was made along the dorsum of the penis to the tip of the glans penis.
Results: Total 50 children presented with micropenis. Their mean age was 10.06 ± 4.07 years (range: 3-15 years). In children less than 10 years of age, mean penile length increased significantly after hormonal treatment from 16.08 mm to 36.73 mm (Table 2). In children greater than 10 years, serum testosterone level increased significantly after 8 weeks of hormonal treatment from <20.5 to 457.44 ±7.23 ng/ml (P < 0.0001). The mean penile length also increased significantly from 26.53 mm to 65.39 mm (P < 0.001). In the older children, mean testicular volume increased from 8.01 cc to 9.70 cc on the left side and from 5.42 cc to 6.97 cc on the right side (P < 0.005) after hormonal treatment. There were no significant adverse events related to the hormonal treatment.
Conclusion: Exogenous administration of testosterone to pre-pubertal boys and hCG to pubertal or post-pubertal boys results in significant increase in stretched penile length. This may be the primary form of treatment for micropenis in these children.
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