PHARMACOGNOSTICAL AND PHRAMACEUTICAL ANALYSIS OF LAXMINARAYAN RASA VATI: AN AYURVEDIC HERBOMENERAL FORMULATION
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 11, Pages 8677-8684
Abstract
Introduction: Post Chikungunya Arthralgia is a major health issue in present era as there is persistent Arthralgia seen in many patients of chikungunya fever after treatment. The disease is characterized by a sudden onset of high-grade fever, rash and arthralgia. The current literature reports that CHIKV can result in a severe chronic arthralgia and/or arthritis that can last months to years following the initial infection.In Ayurveda, Vaatdosha performs all the activity in body including the movements of the joints. When Vaatdosha at Sandhisthan is vitiated and mixed with Aamdosha it produces symptoms like Sandhishool, Sandhishoth and Sashoolkriya or stiffness in joints. There are many formulations mentioned for treatment for such conditions. Laxminrayan rasa vati is classicle Ayurvedic herbomineral formulation cited in Yogratnakara Samhita in context of Vaatvyadhi Chikitsa hence selected for concerned research work of post chikungunya arthralgia.Material and methods: Formulation is made in tablet form. This paper is made to standardize the formulation through Pharmacognostical and Pharmaceutical measures. The formulation was analysed and standardized scientifically through qualitative and quantitative analysis by physico-chemical parameters and High-Performance Thin Layer Chromatography (HPTLC) and pharmacognostical measures.
Results and Discussion: Pharmacognostical analysis showed characteristics of all the ingredient drugs in the tablet. In Pharmaceuticals analysis, HPTLC was done in Toluene, Ethyl acetate, Acetic acid (7:2:1) in which 10 and 4 spots were distinguished at 254 nm and 366 nm respectively. This study may be used as reference standard in the further researches.
KEY-WORDS: Laxminrayan rasa vati, Pharmacognostical, Pharmaceutical, Post Chikungunya arthralgia
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