European Journal of Molecular & Clinical Medicine

Abstract

Background: The prevalence of gastro-esophageal varices in patients with cirrhosis
ranges from 40 to 80%.The most lethal complication of cirrhosis is Upper GIT
Bleeding (UBG) caused by rupture of oesphageal and gastric varices, with a mortality
rate of 17 to 57 percent.We aimed at evaluation of platelet count splenic diameter ratio
(PSR) and Liver stiffness, spleen size to platelet count ratio risk score (LSPS) for
prediction of oesophageal varices.
Patients and methods: this study included 51 patients with compensated cirrhosis.
Screening upper endoscopy was done for detection of OV. They also evaluated by
transient elastography, laboratory tests and divided according to the presence of OV.
We compared both groups based onLSPS,ALBI-PLT score and PSR.
Results:LSPS ratio had sensitivity 87.88% and specificity 88.89% for prediction of
OV.Regarding Platelet count /Splenic diameter ratio the cut off value for prediction of
OV was 909.09 with sensitivity 87.9% and specificity 88.9%.ALBI-PLT scorehad
sensitivity 75.8%and specificity72.2%.
Conclusion: ALBI-PLT score, PSR and LSPS provided good diagnostic toolfor
prediction of oesophagealvarices. The combination of LS with PSR did not have
valuable increase in sensitivity or specificity.