European Journal of Molecular & Clinical Medicine

Abstract

Background:Diabetic kidney disease (DKD) is defined as kidney disease attributed
to diabetes. Diabetic nephropathy (DN) is a common micro vascular complication
of diabetes .DN develops in 15-20% of subjects with T1DM and in similar or higher
percentage of T2DM patients, causing increased morbidity and premature
mortality. American Diabetes Association (ADA) recommends screening for
nephropathy 5 years after diagnosis for type 1 diabetes and at diagnosis for type 2
diabetes.Aim: To estimate the occurrence of diabetic nephropathy in children and
adolescent diagnosed with diabetes Method: A case control study was carried on
one hundred and fifty of children went to pediatrics clinics of zagazig university
hospital. They were classified in to 75 diabetic children who were type 1DM for
more than 4 years and their age less than 18 years old and 75 non diabetic children
of the same gender and age. Both groups under go full history, clinical and
laboratory investigations during the period from December 2018 to November 2019.
Result: frequency of persistent microalbuminuria and hypertension among diabetic
patients were 293 per 1000 and 160 per 1000patient respectively.Conclusion: Type1
diabetic children and adolescent are liable for the occurrence of early diabetic
nephropathy so intensive diabetes therapy is needed, regular screening for MA and
measurement and interpretation of BP and GFR