European Journal of Molecular & Clinical Medicine

Abstract

Background: Dysfunction and anatomic abnormalities of the thyroid are among the most
common diseases of the endocrine glands. Almost one-third of the world’s population lives
in areas of iodine deficiency and present study determines the association ofglycated
haemoglobin level in non-diabetic overt hypothyroid patient.
Materials & Methods:130 subjects of both genders were divided into 2 groups. Group I
comprised of 70 patients with overt hypothyroidism and group II were 60 subjects (control
group) with no thyroid dysfunction. HbA1c was measured by immunoturbidimetry method
by clinical chemistry analyzer and serum TSH and FT4 were measured by radio immune
assay.
Results: Common clinical features were hoarseness of voice in 65%, fatigue in 53%,
weight gain in 70%, depression in 42%, puffy face in 35%, non- pitting edema in 39%, cold
intolerance in 31% and constipation in 22%. The mean TSH level in group I was 18.2
mIU/l and in group II was 3.4 mIU/l, FT4 level was 5.0 pmol/l in group I and 12.4 pmol/l
in group II, HbA1c level was 5.9% in group I and 5.2% in group II and FBS level was 5.2
mmol/l in group I and 4.7 mmol/l in group II. The difference was significant (P< 0.05).
There was correlation between TSH and HbA1c levels (r- 0.412, p< 0.05).
Conclusion: Hypothyroid patients had high level of glycatedhemoglobin level as compared
to control subjects