European Journal of Molecular & Clinical Medicine

Abstract

Background: Vitamin D insufficiency and deficiency are prevalent in almost half the
healthy population of developed countries. The role of vitamin D in the pathogenesis of
Chronic liver diseases (CLDs) is not fully understood.Hence; the present study was
conducted with the aim of assessing the prevalence of vitamin D deficiency among chronic
liver diseases patients and its correlation with severity of liver diseases.Materials &
methods: A total of 50 patients with presence of chronic liver diseases were included.
Complete demographic and clinical details of all the patients were obtained. A Performa
was made and spectrum of clinical profile of all the patients was recorded. Blood samples
were obtained and serum vitamin D levels were obtained using auto-analyzer. Grading of
the patients was done using Child-Pugh Score grading. All the results were recorded and
analyzed by SPSS software.Results: Vitamin D deficiency was seen in 84 percent of the
patients. Vitamin D levels among patients with Grade A, Grade B and Grade C of Child-
Pugh score grade was found to be 32.36 ng/mL, 22.12 ng/mL and 16.48 ng/mL
respectively. Significant results were obtained while correlating Vitamin D levels with
Child-Pugh grade.Conclusion: Patients with chronic liver diseases have significantly
altered Vitamin D metabolism. Hence; Vitamin D deficiency directly correlates with
severity of disease.