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  2. Volume 7, Issue 1
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Online ISSN: 2515-8260

Volume7, Issue1

Improvement of adherence to treatment in patients with nonmuscle invasive bladder cancer (NMIBC) by spreading the 12 months maintenance Bacillus Calmette-Guerin (BCG) regimen over 18 months

    Rani Zreik Boris Friedman Nitza Hirshberg Gal Rinott Mizrahi Yael Hod Ghazi Fari Freifeld Yuval Avi Stein Yoram Dekel

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 30-34

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Abstract

Purpose - To evaluate what effect spreading the maintenance BCG regimen from 12 to 18 months has on the treatment completion rate. Patients and methods - Retrospective data about patients diagnosed with intermediate or high risk nonmuscle invasive bladder cancer were collected. Suggested regimen started with 6 weekly induction intravesical full dose BCG instillations followed by 3 weekly instillations, 3 months after the 6th instillation. Thereafter, 3 weekly instillations were delivered 6 months after the 9th and the 12th instillation. In total, 15 BCG instillations were administered within 18 months. Cystoscopy and urine cytology were performed one month following the 6th, 9th, 12th and 15th instillations and then according to guidelines Results - 195 patients met the inclusion criteria. 190 (97.4%) patients completed the induction instillations and 141 (72.3%) completed the treatment protocol. 39 patients discontinued treatment for medical reasons and 15 patients due to non-compliance. 162 patients completed follow up as recommended for a median of 46±20.1 months. Of those, 45 patients (27.8%) and 8 (4.9%) had disease recurrence and progression, respectively. Conclusion - Spreading BCG instillations during maintenance protocol might achieve a better treatment completion rate, mainly due to improved patient compliance. No impacts on recurrence and progression rates have been observed in our cohort. Prospective randomized trials are warranted before suggesting clinical application.
Keywords:
    non muscle invasive bladder cancer Maintenance BCG irrigations Completion rate Treatment sreading compliance
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(2020). Improvement of adherence to treatment in patients with nonmuscle invasive bladder cancer (NMIBC) by spreading the 12 months maintenance Bacillus Calmette-Guerin (BCG) regimen over 18 months. European Journal of Molecular & Clinical Medicine, 7(1), 30-34.
Rani Zreik; Boris Friedman; Nitza Hirshberg; Gal Rinott Mizrahi; Yael Hod; Ghazi Fari; Freifeld Yuval; Avi Stein; Yoram Dekel. "Improvement of adherence to treatment in patients with nonmuscle invasive bladder cancer (NMIBC) by spreading the 12 months maintenance Bacillus Calmette-Guerin (BCG) regimen over 18 months". European Journal of Molecular & Clinical Medicine, 7, 1, 2020, 30-34.
(2020). 'Improvement of adherence to treatment in patients with nonmuscle invasive bladder cancer (NMIBC) by spreading the 12 months maintenance Bacillus Calmette-Guerin (BCG) regimen over 18 months', European Journal of Molecular & Clinical Medicine, 7(1), pp. 30-34.
Improvement of adherence to treatment in patients with nonmuscle invasive bladder cancer (NMIBC) by spreading the 12 months maintenance Bacillus Calmette-Guerin (BCG) regimen over 18 months. European Journal of Molecular & Clinical Medicine, 2020; 7(1): 30-34.
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