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  2. Volume 8, Issue 3
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Online ISSN: 2515-8260

Volume8, Issue3

Urinary Tissue Inhibitor of Metalloproteinases-2 as Early Biomarker of Acute Kidney Injury after Cardiac Surgery

    Esam El–Din Mahmoud Lotfy Omar MD, Adel Abd El-Mohsen Ghorab MD, Heba S. Abdel-Aziz Assal MD, LamiaaAbd El-Wahab Mohamed, Emad A. William, Maii Mahmoud Ahmed Temraz

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3759-3770

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Abstract

Background: Tissue inhibitor of metalloproteinase-2 (TIMP-2) is a member of the
matrix metalloproteinase family, inducer of G1 cell cycle arrest, it is a marker of
cellular stress in the early phase of tubular cell injury caused by a wide variety of
insults
Aim and objectives: The aim of this work was to study if urinary TIMP-2 can be used
as one of early biomarkers of acute kidney injury after cardiac surgery.
Subjects and Methods: This was cross sectional study was conducted in collaboration
between the Internal Medicine, Cardiothorathic and Clinical pathology departments,
Faculty of Medicine, Zagazig University Hospitals. A total number of 50 patients
were included and classified into two main groups: Group I : included 25 patients
who undergone coronary artery bypass graft. Group II: included 25 patients who
undergone valve replacement surgery. The patients were reclassified after the
procedure into two groups: AKI group: defined on 24 h creatinine level elevation
either by 25% of the basal level or by 0.3 mg/dl above the basal level. No AKI group:
No rise of the serum creatinine level after 24 hours of the operation. The duration of
the study ranged from12- 18 months.
Keywords:
    Tissue inhibitor of metalloproteinase-2 cystatin C Acute kidney injury cardiac surgery
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(2021). Urinary Tissue Inhibitor of Metalloproteinases-2 as Early Biomarker of Acute Kidney Injury after Cardiac Surgery. European Journal of Molecular & Clinical Medicine, 8(3), 3759-3770.
Esam El–Din Mahmoud Lotfy Omar MD, Adel Abd El-Mohsen Ghorab MD, Heba S. Abdel-Aziz Assal MD, LamiaaAbd El-Wahab Mohamed, Emad A. William, Maii Mahmoud Ahmed Temraz. "Urinary Tissue Inhibitor of Metalloproteinases-2 as Early Biomarker of Acute Kidney Injury after Cardiac Surgery". European Journal of Molecular & Clinical Medicine, 8, 3, 2021, 3759-3770.
(2021). 'Urinary Tissue Inhibitor of Metalloproteinases-2 as Early Biomarker of Acute Kidney Injury after Cardiac Surgery', European Journal of Molecular & Clinical Medicine, 8(3), pp. 3759-3770.
Urinary Tissue Inhibitor of Metalloproteinases-2 as Early Biomarker of Acute Kidney Injury after Cardiac Surgery. European Journal of Molecular & Clinical Medicine, 2021; 8(3): 3759-3770.
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