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  2. Volume 8, Issue 3
  3. Author

Online ISSN: 2515-8260

Volume8, Issue3

Recent Modality in the Treatment of Recalcitrant Dermatophytosis

    Fathia Mohamed Khattab, MD; Aya Abd-Elbaset, Msc; Mohamed Taha, MD; Basma Magdy Elkholy, MD

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3771-3777

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Abstract

Background:Dermatophytosis is a common skin diseasein Egypt. It iscaused by
keratinophilic fungi. Tinea become chronic, recurrent and resistant to traditional
therapies. Isotretinoin is a good adjuvant to systemic antifungal in chronic
dermatophytosis due to its keratolytic effect.
Aim: This is a prospective study to assess the effectiveness of combined oral
itraconazole/isotretinoin therapyin the treatment of chronic and recalcitrant
dermatophytosis.
Patients and Methods:A total of 30 patients with chronic and/or recalcitrant
dermatophytosis were included. Potassium hydroxide microscopy was performed.All
the patients received combined oral itraconazole/isotretinoin therapy;Itraconazole
200 mg twice daily with adjuvant isotretinoin20 mg dailyfor 6 weeks. The patients
were followed up to 6 monthsfor signs of recurrence.
Results:Mycological cure was observed in83.3% andcomplete cureoccurred in 70%
of the patients.
Conclusions: Combined oral itraconazole/isotretinoin therapycould be an effective
treatment in recalcitrant dermatophytosis.
Keywords:
    Itraconazole Isotretinoin recalcitrant dermatophytosis`
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(2021). Recent Modality in the Treatment of Recalcitrant Dermatophytosis. European Journal of Molecular & Clinical Medicine, 8(3), 3771-3777.
Fathia Mohamed Khattab, MD; Aya Abd-Elbaset, Msc; Mohamed Taha, MD; Basma Magdy Elkholy, MD. "Recent Modality in the Treatment of Recalcitrant Dermatophytosis". European Journal of Molecular & Clinical Medicine, 8, 3, 2021, 3771-3777.
(2021). 'Recent Modality in the Treatment of Recalcitrant Dermatophytosis', European Journal of Molecular & Clinical Medicine, 8(3), pp. 3771-3777.
Recent Modality in the Treatment of Recalcitrant Dermatophytosis. European Journal of Molecular & Clinical Medicine, 2021; 8(3): 3771-3777.
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Email:  editor.ejmcm21@gmail.com

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