A study on identify the common allergens causing contact dermatitis article
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 11, Pages 9220-9228
Contact dermatitis is an inflammatory eczematous skin disease. It is caused by chemicals or
metal ions that exert toxic effects without inducing a T-cell response (contact irritants) or by
small reactive chemicals that modify proteins and induce innate and adaptive immune
responses (contact allergens).
Material and Methods
A total of 100 patients of contact dermatitis of either sex who attended the Out-Patient
Department of Dermatology, Venereology and Leprosy at Tertiary care teaching hospital
over a period constituted the subject material for the present study. Inclusion Criteria:
Patients clinically suspected to have contact dermatitis. Patients with active dermatitis were
first treated and then subjected to patch testing so as to avoid false positivity and excited skin
syndrome (Angry back syndrome).
Result: In our study males (51%) outnumbered females (49%) in the study. Itching was the
most common symptom (98%) followed by burning and oozing (10%). In this study, most
commonly observed period was 1-5 years, as seen in 57% of the cases. Study sensitization to
one antigen was seen in 40% cases, to two antigens in 27% cases, three antigens in 2% cases.
Negative results observed in 31 % cases. Positive patch test results were noted commonly
among the following occupations were labour (85.71%), farmer (66.66%), housewife
(62.96%), mason (53.33%) cases respectively. Cosmetic allergens (P<0.0001) significantly
more common in females. Parthenium (P<0.05) significantly more common in males.
In our study, the commonest allergens in our patients from hospital adjoining places were
potassium bichromate, thiuram mix and parthenium in males, whereas nickel, fragrance mix
and kumkum in females. In view of the differences in clinical patterns, positivity rates etc.
reported from different parts of India, we owe it to our patients to clarify the epidemiology of
this important problem.
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