European Journal of Molecular & Clinical Medicine

Abstract

The kidney is an important organ having not only excreting function but also other functions such as production of the substances that activates a living body, enzymatic reaction, immunization etc.After administration ethanol and its metabolites go through kidneys and are excreted into urine, and its content in the urine is higher than that of the blood and the liver. Chronic ethanol administration decreases the renal tubular reabsorption and reduces renal function. This study was conducted to examine the association of alcohol consumption with the change and rapid decline in kidney function. 25 adult patients who are moderate alcoholics, 25 patients who are severe alcoholics and 25 adult patients who are non-alcoholics were included in study. Blood Urea and Serum creatinine were investigated. These kidney function parameters were compared between alcoholic and non-alcoholic subjects. In our study Mean blood urea was 48.96 ± 14.62 in alcoholic subjects and 26.62 ± 10.12 in non alcoholic subjects and this difference was statistically significant p value 0.012. Mean serum creatinine was 1.17 ± 1.02  in alcoholic subjects and 0.68 ± 0.22 in non alcoholic subjects and this difference was statistically significant p value 0.017.This shows that moderate to severe alcohol consumption can decline Renal functions.