European Journal of Molecular & Clinical Medicine

Abstract

Background: Ovarian cancer (OC) is considered the most lethal cancer of the female
reproductive system and ranked as the seventh most frequent cancer diagnosed
worldwide and the eighth leading cause of cancer-related death among women
worldwide. The most common type of Ovarian cancer is that originate from the ovarian
surface epithelium "Epithelial ovarian cancer" (EOC) which accounts for over 90% of
all ovarian malignancies and is the most lethal gynecologic malignancy. Sex
determining region Y-box 2 (SRY)-box 2 (SOX2) is one of the main members of the
Sox family which consists of at least 20 members that are divided into 8 groups (from A
to H, based on their high mobility group (HMG) sequence identity in humans). SOX2
expression has been reported at both the RNA and protein levels for many tumors, data
available from The Cancer Genome Atlas indicates that SOX2 mRNA is elevated in
many cancers, relative to normal tissue. The level of SOX2 expression in a tumor
represents a prognostic factor to determine the clinical outcome for a cancer patient.
As SOX2 has a great role in cancer stemness so SOX2 expression in OC is an
interesting issue for studying.