European Journal of Molecular & Clinical Medicine

Abstract

The case-control study was aimed to evaluate the effect of IL-4 and IL-6 gene
polymorphism on susceptibility to pulmonary tuberculosis in patients in Babylon province
and also measure the serum level of these cytokine in in sera of studied group. The
genotype association of rs2243250 (C/C, C/T, T/T) were significant (P<0.05) with (46.7,
38.3, 15)% respectively for PTB cases and (36.7, 26.6, 36.7)% respectively for control
group. Allele's frequency for patients and control for IL-4 (rs2243250) were also
significant (P<0.05) and the C allele represent the risk allele for PTB patients with odd
ratio (95% CI) of 1.93(1.15-3.24), while the T allele represent protective allele for control
group 0.52 (0.31-0.87). The genotype association of rs1800796 (C/C, G/C, G/G) were
significant (P<0.05) with (43.3, 38.3, 18.4)% respectively for PTB cases and (50, 15, 35)%
respectively for control group, whereas, the allele's frequency for patients and control of
IL-6 (rs1800796) were insignificant with (P>0.05). There was a significant difference in
mean level of both IL-4 and IL-6 serum concentration between pTB patients and controls
(P<0.01). Also, there were an insignificant effect of IL-4 (rs2243250) and IL-6 (rs1800796)
gene polymorphism on the difference in serum level of both IL-4 and IL-6 respectively in
studied groups (P>0.05).