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  2. Volume 7, Issue 2
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Online ISSN: 2515-8260

Volume7, Issue2

May Intrauterine Granulocyte Colony Stimulating Factor Improve Clinical & Ongoing Pregnancy & Live Birth Rates in Unexplained Repeated Implantation Failure Patients? A Randomized Clinical Trial

    Atousa Karimi Sara Mokhtar Mohammad Reza Sadeghi Simin Zafardoust Mina Ataei Aboulzal Ghoodjani Arash Mohazzab Fataneh Nazari Soheila Ansaripour

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 82-87

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Abstract

Introduction & Objective: To study whether intrauterine granulocyte colony
stimulating factor (G-CSF) improves the rates of clinical and ongoing pregnancy and
live birth rates in unexplained repeated implantation failure (RIF) patients on their new
ICSI-ET program.
Study Design: In University affiliated, Avicenna specialized center for fertility and
repeated miscarriages 93 consenting unexplained RIF patients with normal
endometrium and without any history of malignancy or uncontrolled background
disease were enrolled in a registered, computer generated randomized double
blinded placebo-controlled clinical trial. Patients underwent intrauterine perfusion of
G-CSF or Placebo before ET and were monitored to calculate the Clinical & ongoing
pregnancy and live birth rates in each group.
Result: The mean age was 32.85±5.02 years in G-CSF and 33.57±4.63 years in
placebo group. There were no differences in baseline characteristic of patients and
the ICSI protocols in groups. clinical and ongoing pregnancy and live birth rates were
17%, 14.9% and 12.8% in G-CSF group and 21.4%, 17.4 %and 13 % in control
group respectively and did not show any statistically significant difference between
the two groups. No adverse side effect was seen in the study groups.
Conclusions: In the study, intrauterine G-CSF did not affect clinical and ongoing
pregnancy and live birth rates There was a non- significant improvement in clinical
and ongoing pregnancy rate and also a reduction in the first trimester abortion in GCSF
patients. Non-significant higher ongoing pregnancy and lower abortion rates in
the G-CSF group may be due to limited sample size or low G-CSF dosage. So further
multicenter studies with larger sample size or higher doses of G-CSF is
recommended. Clinical Trial Registration Number: IRCT2013063011653N2.
Keywords:
    G-CSF Recurrent Implantation failure Pregnancy rate Randomized controlled trial
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(2020). May Intrauterine Granulocyte Colony Stimulating Factor Improve Clinical & Ongoing Pregnancy & Live Birth Rates in Unexplained Repeated Implantation Failure Patients? A Randomized Clinical Trial. European Journal of Molecular & Clinical Medicine, 7(2), 82-87.
Atousa Karimi; Sara Mokhtar; Mohammad Reza Sadeghi; Simin Zafardoust; Mina Ataei; Aboulzal Ghoodjani; Arash Mohazzab; Fataneh Nazari; Soheila Ansaripour. "May Intrauterine Granulocyte Colony Stimulating Factor Improve Clinical & Ongoing Pregnancy & Live Birth Rates in Unexplained Repeated Implantation Failure Patients? A Randomized Clinical Trial". European Journal of Molecular & Clinical Medicine, 7, 2, 2020, 82-87.
(2020). 'May Intrauterine Granulocyte Colony Stimulating Factor Improve Clinical & Ongoing Pregnancy & Live Birth Rates in Unexplained Repeated Implantation Failure Patients? A Randomized Clinical Trial', European Journal of Molecular & Clinical Medicine, 7(2), pp. 82-87.
May Intrauterine Granulocyte Colony Stimulating Factor Improve Clinical & Ongoing Pregnancy & Live Birth Rates in Unexplained Repeated Implantation Failure Patients? A Randomized Clinical Trial. European Journal of Molecular & Clinical Medicine, 2020; 7(2): 82-87.
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