• Register
  • Login

European Journal of Molecular & Clinical Medicine

  • Home
  • Browse
    • Current Issue
    • By Issue
    • By Subject
    • Keyword Index
    • Author Index
    • Indexing Databases XML
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Indexing and Abstracting
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Contact Us
Advanced Search

Notice

As part of Open Journals’ initiatives, we create website for scholarly open access journals. If you are responsible for this journal and would like to know more about how to use the editorial system, please visit our website at https://ejournalplus.com or
send us an email to info@ejournalplus.com

We will contact you soon

  1. Home
  2. Volume 8, Issue 4
  3. Author

Online ISSN: 2515-8260

Volume8, Issue4

Effect Of Midazolam Premedication On Dose Of Propofol When Given As Infusion For Induction Of Anaesthesia: A Randomized Controlled Trial

    Dr. Dewendra J. Gajbhiye

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 298-307

  • Show Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract

Background: Propofol is a popular anaesthetic agent used for induction of general anaesthesia. However, it causes cardio-respiratory depression in vulnerable patients.
Materials and Methods: This prospective, randomized and controlled trial was conducted on 60 patients admitted for elective neurosurgical procedure after ethical clearance from Institutional Ethics Committee. After written informed consent, the patients were randomly allocated to two groups, I and II of 30 each. Group I received Inj. midazolam 0.02 mg/kg as premedication five minutes before induction with propofol infusion. Group II received only propofol infusion for induction of general anaesthesia. Total dose of propofol required for induction of anaesthesia was noted. Haemodynamic parameters were noted from baseline till 08 minutes post laryngoscopy and intubation.
Results: Samples in both the groups were comparable with respect to age, weight and gender. On comparison with the standard bolus dose of propofol (2mg/kg) for induction, reduction in the doses of propofol in Group I and Group II were 0.7 mg/kg and 0.3 mg/kg respectively. The reduction in the dose of propofol in Group I as compared to Group II was 0.4 mg/kg i.e. 20%. This difference was statistically significant (P<0.001). No statistically significant difference in the haemodynamic parameters between the two groups was observed (p>0.05).
Conclusion: Propofol infusion after midazolam premedication reduces the dose of propofol for induction of general anaesthesia and confers haemodynamic stability
Keywords:
  • PDF (498 K)
  • XML
(2021). Effect Of Midazolam Premedication On Dose Of Propofol When Given As Infusion For Induction Of Anaesthesia: A Randomized Controlled Trial. European Journal of Molecular & Clinical Medicine, 8(4), 298-307.
Dr. Dewendra J. Gajbhiye. "Effect Of Midazolam Premedication On Dose Of Propofol When Given As Infusion For Induction Of Anaesthesia: A Randomized Controlled Trial". European Journal of Molecular & Clinical Medicine, 8, 4, 2021, 298-307.
(2021). 'Effect Of Midazolam Premedication On Dose Of Propofol When Given As Infusion For Induction Of Anaesthesia: A Randomized Controlled Trial', European Journal of Molecular & Clinical Medicine, 8(4), pp. 298-307.
Effect Of Midazolam Premedication On Dose Of Propofol When Given As Infusion For Induction Of Anaesthesia: A Randomized Controlled Trial. European Journal of Molecular & Clinical Medicine, 2021; 8(4): 298-307.
  • RIS
  • EndNote
  • BibTeX
  • APA
  • MLA
  • Harvard
  • Vancouver
  • Article View: 191
  • PDF Download: 247
  • LinkedIn
  • Twitter
  • Facebook
  • Google
  • Telegram
Journal Information

Publisher:

Email:  editor.ejmcm21@gmail.com

  • Home
  • Glossary
  • News
  • Aims and Scope
  • Privacy Policy
  • Sitemap

 

For Special Issue Proposal : editor.ejmcm21@gmail.com

This journal is licensed under a Creative Commons Attribution 4.0 International (CC-BY 4.0)

Powered by eJournalPlus